Forkhead box P3 (Q426188)

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mammalian protein found in Homo sapiens
  • forkhead box protein P3
  • FOXP3delta7
  • FOXP3
  • immunodeficiency, polyendocrinopathy, enteropathy, X-linked
  • immune dysregulation, polyendocrinopathy, enteropathy, X-linked
  • scurfin
edit
Language Label Description Also known as
English
Forkhead box P3
mammalian protein found in Homo sapiens
  • forkhead box protein P3
  • FOXP3delta7
  • FOXP3
  • immunodeficiency, polyendocrinopathy, enteropathy, X-linked
  • immune dysregulation, polyendocrinopathy, enteropathy, X-linked
  • scurfin

Statements

image
FOXP3.png
2,100 × 2,100; 1.81 MB
0 references
molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IPI
cell component
nucleus
determination method
IEA
NAS
IDA
8 references
retrieved
5 June 2018
stated in
FOXP3 ensembles in T-cell regulation
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
NAS
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
IEA
retrieved
5 June 2018
stated in
FOXP3 controls regulatory T cell function through cooperation with NFAT
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
5 June 2018
stated in
PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
5 June 2018
stated in
Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
5 June 2018
stated in
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
5 June 2018
stated in
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZS1&geneProductId=UniProtKB:Q9BZS1
determination method
IDA
nucleus
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IEA
retrieved
8 April 2019
stated in
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
FOXP3 controls regulatory T cell function through cooperation with NFAT
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
PDCD5 negatively regulates autoimmunity by upregulating FOXP3(+) regulatory T cells and suppressing Th17 and Th1 responses
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
biological process
positive regulation of transcription, DNA-templated
determination method
ISS
IMP
IEA
IDA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
ISS
retrieved
8 April 2019
stated in
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IMP
retrieved
8 April 2019
stated in
Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IMP
retrieved
8 April 2019
stated in
FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IEA
retrieved
8 April 2019
stated in
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
negative regulation of interleukin-2 production
determination method
IMP
IEA
IDA
5 references
retrieved
8 April 2019
stated in
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IEA
retrieved
8 April 2019
stated in
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
negative regulation of transcription, DNA-templated
determination method
IMP
IEA
IDA
7 references
retrieved
8 April 2019
stated in
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IMP
retrieved
8 April 2019
stated in
Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IEA
retrieved
8 April 2019
stated in
Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
GOA
curator
UniProt
UniProt protein ID
Q9BZS1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
retrieved
8 April 2019
stated in
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZS1
determination method
IDA
Gene Atlas image
PBB GE FOXP3 221333 at fs.png
732 × 530; 12 KB
0 references
PBB GE FOXP3 221334 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Freebase ID
/m/066764
0 references
Microsoft Academic ID
2779727006
0 references
2911219922
0 references
WikiProjectMed ID
FOXP3
0 references
 
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