Interleukin 2 (Q410130)

http://www.ebi.ac.uk/interpro/protein/P60568

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60568

Interleukin-2, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

IL2 Crystal Structure.png
900 × 750; 204 KB

media legend

Structure cristalline de l'IL-2 telle que publiée dans la Protein Data Bank (French)

1 reference

imported from Wikimedia project

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

interleukin-2 receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

glycosphingolipid binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

kinase activator activity

1 reference

8 April 2019

The IL-2 receptor complex: its structure, function, and target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

growth factor activity

The IL-2 receptor complex: its structure, function, and target genes

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

kappa-type opioid receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

carbohydrate binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

protein binding

3 references

8 April 2019

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

Hot-spot mimicry of a cytokine receptor by a small molecule

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

cell component

extracellular region

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60568&geneProductId=UniProtKB:P60568

extracellular space

T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of T cell differentiation

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

negative regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of inflammatory response

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

1 reference

8 April 2019

negative regulation of heart contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

1 reference

8 April 2019

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of regulatory T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

cell-cell signaling

1 reference

8 April 2019

The IL-2 receptor complex: its structure, function, and target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of interferon-gamma production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

natural killer cell activation

1 reference

8 April 2019

The IL-2 receptor complex: its structure, function, and target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

negative regulation of apoptotic process

1 reference

8 April 2019

The IL-2 receptor complex: its structure, function, and target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of dendritic spine development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

negative regulation of lymphocyte proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

1 reference

8 April 2019

regulation of T cell homeostatic proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

T cell differentiation

1 reference

8 April 2019

The IL-2 receptor complex: its structure, function, and target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of cell growth

1 reference

8 April 2019

The IL-2 receptor complex: its structure, function, and target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

cell adhesion

1 reference

8 April 2019

Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of B cell proliferation

1 reference

8 April 2019

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of tissue remodeling

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of cell population proliferation

1 reference

8 April 2019

The IL-2 receptor complex: its structure, function, and target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

negative regulation of B cell apoptotic process

1 reference

8 April 2019

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of isotype switching to IgG isotypes

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of interleukin-17 production

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

negative regulation of inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

positive regulation of activated T cell proliferation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

8 April 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

negative regulation of T-helper 17 cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

leukocyte activation involved in immune response

1 reference

8 April 2019

HMGN2: a novel antimicrobial effector molecule of human mononuclear leukocytes?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

regulation of regulatory T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

1 reference

8 April 2019

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

1 reference

8 April 2019

interleukin-2-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

1 reference

8 April 2019

positive regulation of kinase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60568

http://purl.uniprot.org/uniprot/P60568

Gene Atlas image

PBB GE IL2 207849 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Interleukin-2, conserved site

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60568

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016