Coagulation factor XII (Q339499)

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mammalian protein found in Homo sapiens

Hageman factor
beta-factor XIIa part 1
HAF
beta-factor XIIa part 2
coagulation factor XII
F12
coagulation factor XIIa light chain
coagulation factor XIIa heavy chain

Language	Label	Description	Also known as
English	Coagulation factor XII	mammalian protein found in Homo sapiens	Hageman factor beta-factor XIIa part 1 HAF beta-factor XIIa part 2 coagulation factor XII F12 coagulation factor XIIa light chain coagulation factor XIIa heavy chain

Statements

1 reference

13 November 2019

UniProt protein ID

coagulation factor XII/hepatocyte growth factor activator

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

Kringle-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

Peptidase S1, PA clan

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

Fibronectin type II domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

Kringle superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

Kringle domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fibronectin type II domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Kringle, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fibronectin, type I, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, histidine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, serine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

misfolded protein binding

determination method

1 reference

8 April 2019

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

protein binding

determination method

2 references

8 April 2019

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

serine-type peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

serine-type endopeptidase activity

determination method

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

26 September 2017

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

26 September 2017

Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

calcium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

serine-type endopeptidase activity

determination method

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

1 January 2018

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

1 January 2018

Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

serine-type endopeptidase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

plasma membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

extracellular region

determination method

extracellular exosome

determination method

extracellular space

determination method

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

26 September 2017

Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00748&geneProductId=UniProtKB:P00748

determination method

extracellular space

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

rough endoplasmic reticulum

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

biological process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

response to misfolded protein

determination method

1 reference

8 April 2019

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

positive regulation of plasminogen activation

determination method

1 reference

8 April 2019

Hageman-factor-dependent fibrinolysis: generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

zymogen activation

determination method

3 references

8 April 2019

Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Hageman-factor-dependent fibrinolysis: generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

protein processing

determination method

1 reference

8 April 2019

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

protein autoprocessing

determination method

1 reference

8 April 2019

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

positive regulation of blood coagulation

determination method

1 reference

8 April 2019

Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

positive regulation of fibrinolysis

determination method

1 reference

8 April 2019

Hageman-factor-dependent fibrinolysis: generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

innate immune response

determination method

1 reference

8 April 2019

Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571----Ser substitution

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

regulation of blood coagulation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

plasma kallikrein-kinin cascade

determination method

2 references

Factor XII activation

determination method

1 reference

8 April 2019

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00748

determination method

Gene Atlas image

PBB GE F12 205774 at fs.png
732 × 530; 10 KB

0 references

http://purl.uniprot.org/uniprot/P00748

1 reference

Identifiers.org

serine proteases, trypsin family, histidine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

fibronectin, type I

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

serine proteases, trypsin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

fibronectin type II domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

kringle, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

Serine proteases, trypsin family, serine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00748

Identifiers

MeSH descriptor ID

subject named as

Factor XII

0 references

0 references

D12.776.124.125.450

0 references

D12.776.811.243.500

0 references

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000253496

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000253496

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

24 May 2023

Sitelinks

Wikipedia(19 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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