SRY-box transcription factor 2 (Q21114866)

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mammalian protein found in Homo sapiens
  • SRY-box 2
  • sex determining region Y-box 2
  • SRY-related HMG-box gene 2
  • transcription factor SOX2
  • SRY (sex determining region Y)-box 2
  • SOX2
  • transcription factor SOX-2
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Language Label Description Also known as
English
SRY-box transcription factor 2
mammalian protein found in Homo sapiens
  • SRY-box 2
  • sex determining region Y-box 2
  • SRY-related HMG-box gene 2
  • transcription factor SOX2
  • SRY (sex determining region Y)-box 2
  • SOX2
  • transcription factor SOX-2

Statements

molecular function
DNA binding
determination method
NAS
IDA
IEA
7 references
retrieved
8 April 2019
stated in
The cDNA sequence and chromosomal location of the human SOX2 gene
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
8 April 2019
stated in
SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
8 April 2019
stated in
Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
8 April 2019
stated in
Purification of human transcription factors Nanog and Sox2, each in complex with Skp, an Escherichia coli periplasmic chaperone
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
8 April 2019
stated in
Core transcriptional regulatory circuitry in human embryonic stem cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IDA
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IPI
retrieved
8 April 2019
stated in
Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IPI
retrieved
8 April 2019
stated in
The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IPI
retrieved
8 April 2019
stated in
The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IPI
retrieved
8 April 2019
stated in
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IPI
retrieved
8 April 2019
stated in
Deterministic direct reprogramming of somatic cells to pluripotency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IPI
cell component
nucleus
determination method
IC
NAS
IDA
IEA
8 references
retrieved
27 March 2018
stated in
The cDNA sequence and chromosomal location of the human SOX2 gene
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
NAS
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
27 March 2018
stated in
Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
27 March 2018
stated in
Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
27 March 2018
stated in
SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
27 March 2018
stated in
Core transcriptional regulatory circuitry in human embryonic stem cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48431&geneProductId=UniProtKB:P48431
determination method
IC
nucleus
determination method
IBA
IC
IDA
IEA
NAS
9 references
retrieved
8 April 2019
stated in
The cDNA sequence and chromosomal location of the human SOX2 gene
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IEA
retrieved
8 April 2019
stated in
SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
8 April 2019
stated in
Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
8 April 2019
stated in
Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone
GOA
curator
UniProt
UniProt protein ID
P48431
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IDA
retrieved
8 April 2019
stated in
Core transcriptional regulatory circuitry in human embryonic stem cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48431
determination method
IBA
biological process

Identifiers

Freebase ID
/m/03cx0nt
0 references
 
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