CD28 molecule (Q1622348)

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mammalian protein found in Homo sapiens
  • CD28
  • T-cell-specific surface glycoprotein CD28
  • CD28 antigen
  • TP44
  • CD28 Antigens
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Language Label Description Also known as
English
CD28 molecule
mammalian protein found in Homo sapiens
  • CD28
  • T-cell-specific surface glycoprotein CD28
  • CD28 antigen
  • TP44
  • CD28 Antigens

Statements

molecular function
protein binding
determination method or standard
IPI
12 references
retrieved
8 April 2019
stated in
Mechanism for down-regulation of CD28 by Nef.
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
CD28/B7 costimulation: a review
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of Lck-binding elements in the herpesviral regulatory Tip protein
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
retrieved
8 April 2019
stated in
Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IPI
cell component
biological process
positive regulation of T cell proliferation
determination method or standard
IDA
ISS
TAS
IEA
5 references
retrieved
7 November 2018
stated in
CD28/B7 costimulation: a review
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747
determination method or standard
TAS
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747
determination method or standard
ISS
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747
determination method or standard
IEA
retrieved
7 November 2018
stated in
Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747
determination method or standard
IDA
retrieved
7 November 2018
stated in
Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10747&geneProductId=UniProtKB:P10747
determination method or standard
IDA
positive regulation of T cell proliferation
determination method or standard
IBA
IDA
IEA
TAS
5 references
retrieved
8 April 2019
stated in
CD28/B7 costimulation: a review
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IEA
retrieved
8 April 2019
stated in
Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IDA
retrieved
8 April 2019
stated in
Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen)
GOA
curator
UniProt
UniProt protein ID
P10747
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10747
determination method or standard
IBA
Gene Atlas image
PBB GE CD28 211856 x at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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