CD44 molecule (Indian blood group) (Q1056532)

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mammalian protein found in Homo sapiens

• HUTCH-I
• chondroitin sulfate proteoglycan 8
• epican
• homing function and Indian blood group system
• Indian blood group antigen
• soluble CD44
• Phagocytic glycoprotein I
• hyaluronate receptor
• CD44 antigen
• Hermes antigen
• GP90 lymphocyte homing/adhesion receptor
• CD44
• CDw44
• cell surface glycoprotein CD44
• PGP-1
• extracellular matrix receptor III
• heparan sulfate proteoglycan
• ECMR-III
• PGP-I
• phagocytic glycoprotein 1
• hematopoietic cell E- and L-selectin ligand
• Hyaluronan Receptors
• Hyaluronan Receptor

edit

Language	Label	Description	Also known as
English	CD44 molecule (Indian blood group)	mammalian protein found in Homo sapiens	HUTCH-I chondroitin sulfate proteoglycan 8 epican homing function and Indian blood group system Indian blood group antigen soluble CD44 Phagocytic glycoprotein I hyaluronate receptor CD44 antigen Hermes antigen GP90 lymphocyte homing/adhesion receptor CD44 CDw44 cell surface glycoprotein CD44 PGP-1 extracellular matrix receptor III heparan sulfate proteoglycan ECMR-III PGP-I phagocytic glycoprotein 1 hematopoietic cell E- and L-selectin ligand Hyaluronan Receptors Hyaluronan Receptor

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16070

part of

C-type lectin fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16070

C-type lectin-like/link domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16070

CD44 antigen

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16070

Link domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

image of molecular model or crystal lattice model

Protein CD44 PDB 1poz.png
535 × 431; 106 KB

depicts

ribbon diagram

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16070

encoded by

CD44

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16070

molecular function

collagen binding

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

NAS

protein binding

determination method or standard

IPI

7 references

retrieved

8 April 2019

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IPI

retrieved

8 April 2019

stated in

Measurements of heterotypic associations between cluster of differentiation CD74 and CD44 in human breast cancer-derived cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IPI

retrieved

8 April 2019

stated in

Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IPI

retrieved

8 April 2019

stated in

Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IPI

retrieved

8 April 2019

stated in

CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IPI

retrieved

8 April 2019

stated in

Osteopontin expression is an independent adverse prognostic factor in resectable gastrointestinal stromal tumor and its interaction with CD44 promotes tumor proliferation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IPI

retrieved

8 April 2019

stated in

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IPI

hyaluronic acid binding

determination method or standard

NAS

IDA

IEA

4 references

retrieved

26 September 2017

stated in

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

NAS

retrieved

26 September 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

26 September 2017

stated in

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

26 September 2017

stated in

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

cytokine receptor activity

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

transmembrane signaling receptor activity

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

cytokine receptor activity

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

hyaluronic acid binding

determination method or standard

IBA

IDA

IEA

NAS

5 references

retrieved

8 April 2019

stated in

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

NAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

8 April 2019

stated in

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

cell component

integral component of membrane

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

Golgi apparatus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

macrophage migration inhibitory factor receptor complex

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

focal adhesion

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

plasma membrane

determination method or standard

IDA

TAS

IEA

4 references

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

TAS

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

26 September 2017

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

26 September 2017

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

integral component of plasma membrane

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

NAS

cell surface

determination method or standard

IDA

2 references

retrieved

8 April 2019

stated in

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

extracellular exosome

determination method or standard

IDA

3 references

retrieved

26 September 2017

stated in

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

26 September 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

26 September 2017

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

cytosol

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

secretory granule membrane

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

apical plasma membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

lamellipodium membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

cell projection

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

plasma membrane

determination method or standard

IBA

IDA

IEA

TAS

5 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

8 April 2019

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

microvillus

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

focal adhesion

determination method or standard

HDA

1 reference

retrieved

8 April 2019

stated in

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

HDA

basolateral plasma membrane

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

macrophage migration inhibitory factor receptor complex

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

cell projection

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

8 April 2019

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

extracellular exosome

determination method or standard

HDA

3 references

retrieved

8 April 2019

stated in

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

HDA

retrieved

8 April 2019

stated in

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

HDA

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

HDA

biological process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IMP

monocyte aggregation

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IMP

positive regulation of heterotypic cell-cell adhesion

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IMP

hyaluronan catabolic process

determination method or standard

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

retrieved

8 April 2019

stated in

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

interferon-gamma-mediated signaling pathway

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

extracellular matrix disassembly

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

extracellular matrix organization

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

negative regulation of apoptotic process

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IMP

cellular response to fibroblast growth factor stimulus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

positive regulation of peptidyl-serine phosphorylation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

cartilage development

determination method or standard

IEP

1 reference

retrieved

8 April 2019

stated in

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEP

cell adhesion

determination method or standard

IEA

2 references

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

26 September 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IEA

negative regulation of DNA damage response, signal transduction by p53 class mediator

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

positive regulation of ERK1 and ERK2 cascade

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IDA

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

cell-matrix adhesion

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Expression of CD44 is repressed in neuroblastoma cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

NAS

positive regulation of monocyte aggregation

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IMP

leukocyte migration

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

neutrophil degranulation

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

TAS

wound healing, spreading of cells

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IMP

regulation of lamellipodium morphogenesis

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Podoplanin associates with CD44 to promote directional cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IMP

cell-cell adhesion

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Expression of CD44 is repressed in neuroblastoma cells

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

NAS

inflammatory response

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

cell adhesion

determination method or standard

IBA

IEA

3 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16070&geneProductId=UniProtKB:P16070

determination method or standard

IBA

positive regulation of ERK1 and ERK2 cascade

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

cell adhesion

determination method or standard

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IEA

retrieved

8 April 2019

stated in

Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IBA

cell migration

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CD44 in human glioma correlates with histopathological grade and cell migration

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

T cell activation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Stimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production

GOA

curator

UniProt

UniProt protein ID

P16070

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16070

determination method or standard

IDA

Gene Atlas image

PBB GE CD44 204490 s at tn.png
255 × 135; 847 bytes

1 reference

imported from Wikimedia project

English Wikipedia

has part(s)

Link domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16070

Commons category

Hematopoietic cell E- and/or L-selectin ligand

0 references

Identifiers

MeSH descriptor ID

D018960

subject named as

Hyaluronan Receptors

0 references

MeSH tree code

D09.698.735.200.625

0 references

D12.776.395.550.200.625.144

0 references

D12.776.395.650.750.281

0 references

D12.776.543.550.200.625.144

0 references

D12.776.543.750.705.877.144

0 references

D23.050.301.350.625.144

0 references

D09.400.430.890.200.625.144

0 references

D09.400.430.930.750.281

0 references

RefSeq protein ID

NP_000601

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

NP_001001389

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

NP_001001390

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

NP_001001391

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

NP_001001392

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

NP_001189484

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

NP_001189485

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

NP_001189486

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_005253288

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_005253289

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_005253292

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_005253295

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_005253296

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_005253297

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_006718451

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_006718453

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518784

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518785

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518786

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518787

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518788

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518789

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518790

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_011518791

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_016874072

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_016874073

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

XP_016874074

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

960

UniProt protein ID

P16070

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16070

Ensembl protein ID

ENSP00000263398

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000263398

ENSP00000278386

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000278386

ENSP00000309732

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000309732

ENSP00000389830

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000389830

ENSP00000392331

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000392331

ENSP00000398632

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000398632

ENSP00000404447

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000404447

ENSP00000278385

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000278385

ENSP00000279452

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000279452

ENSP00000395953

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000395953

ENSP00000398099

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000398099

ENSP00000431860

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000431860

ENSP00000432405

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432405

ENSP00000432704

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432704

ENSP00000432718

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432718

ENSP00000433189

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000433189

ENSP00000434418

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000434418

ENSP00000434465

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000434465

ENSP00000434530

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000434530

ENSP00000434920

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000434920

ENSP00000435321

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000435321

ENSP00000435377

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000435377

ENSP00000436451

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000436451

ENSP00000436549

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000436549

ENSP00000436623

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000436623

ENSP00000436980

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000436980

ENSP00000492449

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000492449

Freebase ID

/m/09810r

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

2780932548

0 references

OpenAlex ID

C2780932548

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

archive URL

https://web.archive.org/web/20220125070108/https://docs.openalex.org/download-snapshot/snapshot-data-format

archive date

25 January 2022

PDB structure ID

1POZ

1 reference

stated in

UniProt

UniProt protein ID

P16070

retrieved

9 August 2016

language of work or name

English

1UUH

1 reference

stated in

UniProt

UniProt protein ID

P16070

retrieved

9 August 2016

language of work or name

English

2I83

1 reference

stated in

UniProt

UniProt protein ID

P16070

retrieved

9 August 2016

language of work or name

English

4PZ3

1 reference

stated in

UniProt

UniProt protein ID

P16070

retrieved

9 August 2016

language of work or name

English

4PZ4

1 reference

stated in

UniProt

UniProt protein ID

P16070

retrieved

9 August 2016

language of work or name

English

UMLS CUI

C0243982

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(14 entries)

edit

• arwiki CD44
• cywiki CD44
• dewiki CD44-Antigen
• enwiki CD44
• frwiki CD44 (antigène)
• glwiki CD44
• idwiki CD44
• itwiki CD44
• jawiki CD44
• kowiki CD44
• ruwiki CD44
• ttwiki CD44
• ukwiki CD44
• zhwiki CD44

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(1 entry)

edit

• commonswiki Category:Hematopoietic cell E- and/or L-selectin ligand

Retrieved from "https://www.wikidata.org/w/index.php?title=Q1056532&oldid=2212975346"