mitogen-activated protein kinase 3 (Q6714406)

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extracellular signal-regulated MAP kinase that phosphorylates a number of transcription factors and microtubule-associated proteins
  • p44-ERK1
  • ERK-1
  • insulin-stimulated MAP2 kinase
  • p44-MAPK
  • MAPK3
  • extracellular signal-related kinase 1
  • ERT2
  • microtubule-associated protein 2 kinase
  • MAPK 1
  • extracellular signal-regulated kinase 1
  • MAP kinase isoform p44
edit
Language Label Description Also known as
English
mitogen-activated protein kinase 3
extracellular signal-regulated MAP kinase that phosphorylates a number of transcription factors and microtubule-associated proteins
  • p44-ERK1
  • ERK-1
  • insulin-stimulated MAP2 kinase
  • p44-MAPK
  • MAPK3
  • extracellular signal-related kinase 1
  • ERT2
  • microtubule-associated protein 2 kinase
  • MAPK 1
  • extracellular signal-regulated kinase 1
  • MAP kinase isoform p44

Statements

molecular function
MAP kinase activity
determination method
NAS
IDA
IEA
TAS
6 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
TAS
retrieved
5 June 2018
stated in
Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
NAS
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
5 June 2018
stated in
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IDA
protein binding
determination method
IPI
27 references
retrieved
8 April 2019
stated in
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Erk phosphorylates threonine 42 residue of ribosomal protein S3
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of myofibrillogenesis regulator-1 activates the MAPK signaling pathway and induces proliferation and migration in human breast cancer MCF7 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase Syk regulates TPL2 activation signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of human myoblast differentiation by PEBP4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
retrieved
8 April 2019
stated in
Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IPI
MAP kinase activity
determination method
IBA
IDA
IEA
NAS
TAS
7 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
TAS
retrieved
1 January 2018
stated in
Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
NAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
1 January 2018
stated in
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P27361&geneProductId=UniProtKB:P27361
determination method
IBA
MAP kinase activity
determination method
IBA
IDA
IEA
NAS
6 references
retrieved
8 April 2019
stated in
Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IEA
retrieved
8 April 2019
stated in
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2
GOA
curator
UniProt
UniProt protein ID
P27361
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27361
determination method
IBA
cell component
biological process

Identifiers

MeSH descriptor ID
D048052
subject named as
Mitogen-Activated Protein Kinase 3
0 references
 
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