Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study (Q44846367)

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scientific article published on 19 August 2011

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English	Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study	scientific article published on 19 August 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 December 2017

http://europepmc.org/abstract/MED/21862407

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study (English)

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Europe PubMed Central

PubMed publication ID

6 December 2017

http://europepmc.org/abstract/MED/21862407

ovarian carcinoma

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triple-negative breast cancer

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object named as

Mark Clemons

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6 December 2017

http://europepmc.org/abstract/MED/21862407

Marc Tischkowitz

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object named as

Marc Tischkowitz

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6 December 2017

http://europepmc.org/abstract/MED/21862407

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object named as

Blake Gilks

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6 December 2017

http://europepmc.org/abstract/MED/21862407

author name string

Karen A Gelmon

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6 December 2017

http://europepmc.org/abstract/MED/21862407

Helen Mackay

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http://europepmc.org/abstract/MED/21862407

Kenneth Swenerton

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André Robidoux

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Katia Tonkin

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http://europepmc.org/abstract/MED/21862407

Hal Hirte

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David Huntsman

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http://europepmc.org/abstract/MED/21862407

Rinat Yerushalmi

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Euan Macpherson

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James Carmichael

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Amit Oza

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publication date

19 August 2011

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6 December 2017

http://europepmc.org/abstract/MED/21862407

Lancet Oncology Commission

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http://europepmc.org/abstract/MED/21862407

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852-861

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http://europepmc.org/abstract/MED/21862407

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

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Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

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Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

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BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

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Breast cancer genetics: what we know and what we need

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7 January 2021

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The contribution of BRCA1 and BRCA2 to ovarian cancer

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Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies

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Triple negative breast cancer: unmet medical needs

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Hallmarks of 'BRCAness' in sporadic cancers

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Current understanding of the epidemiology and clinical implications of BRCA1 and BRCA2 mutations for ovarian cancer

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Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

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7 January 2021

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Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer

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American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer

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Optimal two-stage designs for phase II clinical trials

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

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Re: New guidelines to evaluate the response to treatment in solid tumors (ovarian cancer).

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Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan

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Iniparib plus chemotherapy in metastatic triple-negative breast cancer

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PARP inhibition: PARP1 and beyond

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Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach

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A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

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Resistance to therapy caused by intragenic deletion in BRCA2

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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

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Identifiers

10.1016/S1470-2045(11)70214-5

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

http://europepmc.org/abstract/MED/21862407

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

http://europepmc.org/abstract/MED/21862407

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