ghrelin (Q422269)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBU3

Synthesis, secretion, and deacylation of Ghrelin

0 references

1 reference

Gene Ontology release 2019-11-16

Ghrelin and obestatin prepropeptide

0 references

mass

3,243.778215 dalton

1 reference

English

title

Gastric MLTRP (English)

8 October 2016

chemical formula

C₁₄₁H₂₃₅N₄₇O₄₁

1 reference

protein tyrosine kinase activator activity

English

title

Gastric MLTRP (English)

8 October 2016

1 reference

16 January 2019

1 reference

16 January 2019

IMP

1 reference

8 April 2019

Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

IMP

hormone activity

3 references

protein binding

IPI

1 reference

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

IPI

ghrelin receptor binding

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

growth hormone-releasing hormone activity

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

27 March 2018

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

growth hormone-releasing hormone activity

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

ghrelin receptor binding

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

cell component

postsynapse

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

endoplasmic reticulum lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

1 reference

8 April 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

axon

1 reference

8 April 2019

Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

secretory granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

1 reference

8 April 2019

extracellular space

2 references

27 March 2018

Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

27 March 2018

Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

extracellular space

Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

Schaffer collateral - CA1 synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

G protein-coupled receptor signaling pathway

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

4 references

8 April 2019

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of cortisol secretion

2 references

8 April 2019

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of growth hormone receptor signaling pathway

1 reference

8 April 2019

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

negative regulation of insulin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of corticotropin secretion

1 reference

8 April 2019

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

negative regulation of locomotion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

cortisol secretion

1 reference

8 April 2019

Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

response to estrogen

1 reference

8 April 2019

Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

negative regulation of endothelial cell proliferation

1 reference

8 April 2019

Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of circadian sleep/wake cycle, non-REM sleep

1 reference

8 April 2019

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

cartilage development

1 reference

8 April 2019

The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

decidualization

1 reference

8 April 2019

Facilitation of decidualization by locally produced ghrelin in the human endometrium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

regulation of cell population proliferation

2 references

8 April 2019

Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

growth hormone secretion

1 reference

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of growth hormone secretion

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

27 March 2018

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

27 March 2018

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

excitatory postsynaptic potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

hormone-mediated signaling pathway

1 reference

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

glucose metabolic process

1 reference

8 April 2019

Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of multicellular organism growth

1 reference

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

negative regulation of angiogenesis

1 reference

8 April 2019

Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

response to hormone

1 reference

8 April 2019

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

actin polymerization or depolymerization

1 reference

8 April 2019

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of response to food

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

negative regulation of circadian sleep/wake cycle, REM sleep

1 reference

8 April 2019

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

negative regulation of inflammatory response

1 reference

27 March 2018

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

positive regulation of protein tyrosine kinase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

adult feeding behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

response to nutrient levels

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of eating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of adipose tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

negative regulation of interleukin-1 beta production

gastric emptying

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

response to electrical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

regulation of transmission of nerve impulse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of bone development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of sprouting angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of gastro-intestinal system smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of small intestine smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

regulation of gastric motility

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of vascular endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of growth rate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of small intestinal transit

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of gastric mucosal blood circulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

positive regulation of feeding behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

energy homeostasis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

negative regulation of inflammatory response

positive regulation of growth hormone secretion

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

postsynaptic modulation of chemical synaptic transmission

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

regulation of postsynapse organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

http://purl.uniprot.org/uniprot/Q9UBU3

exact match

1 reference

https://www.uniprot.org/uniprot/Q9UBU3#PRO_0000019202

Identifiers.org

0 references

has part(s)

Motilin/ghrelin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBU3

Motilin/ghrelin-associated peptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBU3

Commons category

Ghrelin

0 references

Identifiers

J9U ID

987007539702105171

1 reference

National Library of Israel

Library of Congress authority ID

sh2004000537

subject named as

Ghrelin

1 reference

Nuovo soggettario

https://thes.bncf.firenze.sbn.it/termine.php?id=49457

GNKDKYIHGQKHHM-RJKLHVOGSA-N

16 June 2021

InChIKey

1 reference

ChEBI release 2020-09-01

1 reference

ghrelin (English)

8 October 2016

1 reference

English

title

Glycyl-L-seryl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-seryl-L-lysyl- (English)