BRCA2 DNA repair associated (Q421651)

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mammalian protein found in Homo sapiens
  • breast cancer 2 tumor suppressor
  • breast and ovarian cancer susceptibility protein 2
  • mutant BRCA2
  • Fanconi anemia group D1 protein
  • BRCA1/BRCA2-containing complex, subunit 2
  • breast cancer type 2 susceptibility protein
  • breast and ovarian cancer susceptibility gene, early onset
  • breast cancer 2, early onset
  • BRCA2
  • truncated breast cancer 2
  • BRCA2 Protein
edit
Language Label Description Also known as
English
BRCA2 DNA repair associated
mammalian protein found in Homo sapiens
  • breast cancer 2 tumor suppressor
  • breast and ovarian cancer susceptibility protein 2
  • mutant BRCA2
  • Fanconi anemia group D1 protein
  • BRCA1/BRCA2-containing complex, subunit 2
  • breast cancer type 2 susceptibility protein
  • breast and ovarian cancer susceptibility gene, early onset
  • breast cancer 2, early onset
  • BRCA2
  • truncated breast cancer 2
  • BRCA2 Protein

Statements

image
PBB Protein BRCA2 image.jpg
500 × 500; 30 KB
0 references
molecular function
protein binding
determination method
IPI
44 references
retrieved
8 April 2019
stated in
Highlight: BRCA1 and BRCA2 proteins in breast cancer
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
BRCA2 suppresses cell proliferation via stabilizing MAGE-D1
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
BRCA2 and homologous recombination
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
PALB2 regulates recombinational repair through chromatin association and oligomerization
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Purified human BRCA2 stimulates RAD51-mediated recombination
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of albumin-associated peptides and proteins from ovarian cancer patients
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Resistance to therapy caused by intragenic deletion in BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of PALB2/FANCN-associated breast cancer families
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Purified human BRCA2 stimulates RAD51-mediated recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
A mechanism for the suppression of homologous recombination in G1 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
DSS1 is required for the stability of BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for recruitment of BRCA2 by PALB2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
8 April 2019
stated in
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IPI
protein binding
determination method
IBA
IPI
44 references
retrieved
1 January 2018
stated in
BRCA2 suppresses cell proliferation via stabilizing MAGE-D1
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Highlight: BRCA1 and BRCA2 proteins in breast cancer
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
BRCA2 and homologous recombination
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Analysis of albumin-associated peptides and proteins from ovarian cancer patients
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Purified human BRCA2 stimulates RAD51-mediated recombination
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
PALB2 regulates recombinational repair through chromatin association and oligomerization
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis for recruitment of BRCA2 by PALB2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Purified human BRCA2 stimulates RAD51-mediated recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
DSS1 is required for the stability of BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
A mechanism for the suppression of homologous recombination in G1 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Analysis of PALB2/FANCN-associated breast cancer families
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Resistance to therapy caused by intragenic deletion in BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IPI
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IBA
cell component
nucleus
determination method
IDA
IEA
5 references
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IEA
retrieved
24 April 2018
stated in
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IDA
retrieved
24 April 2018
stated in
Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IDA
retrieved
24 April 2018
stated in
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51587&geneProductId=UniProtKB:P51587
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IEA
retrieved
8 April 2019
stated in
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IDA
retrieved
8 April 2019
stated in
Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IDA
retrieved
8 April 2019
stated in
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
GOA
curator
UniProt
UniProt protein ID
P51587
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51587
determination method
IBA
biological process
Gene Atlas image
PBB GE BRCA2 208368 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D024682
subject named as
BRCA2 Protein
0 references
MeSH tree code
D12.776.313.249
0 references
D12.776.624.776.101
0 references
D12.776.660.105
0 references
 
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