DNA damage checkpoints in mammals (Q36325437)

13 August 2017

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title

DNA damage checkpoints in mammals (English)

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13 August 2017

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Hiroyuki Niida

1

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13 August 2017

Makoto Nakanishi

series ordinal

2

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13 August 2017

publication date

28 November 2005

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13 August 2017

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13 August 2017

volume

21

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13 August 2017

issue

1

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13 August 2017

page(s)

3-9

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Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex

13 August 2017

cites work

1 reference

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A unified view of the DNA-damage checkpoint

21 January 2018

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DNA damage checkpoint in budding yeast.

21 January 2018

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Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC.

21 January 2018

1 reference

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Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy

21 January 2018

1 reference

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Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway

21 January 2018

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A novel Rad24 checkpoint protein complex closely related to replication factor C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae

21 January 2018

1 reference

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

1 reference

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

53BP1, a mediator of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Hallmarks of 'BRCAness' in sporadic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

ATM: genome stability, neuronal development, and cancer cross paths

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

ATR and ATRIP: partners in checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

ATR and ATM regulate the timing of DNA replication origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

A kinase from fission yeast responsible for blocking mitosis in S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Regulation of p53 localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Mouse development and cell proliferation in the absence of D-cyclins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Cdk2-dependent and -independent pathways in E2F-mediated S phase induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Dual roles of ATM in the cellular response to radiation and in cell growth control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

Polo-like kinase-1 is a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEI063

21 January 2018

Identifiers

DOI

10.1093/MUTAGE/GEI063

1 reference

13 August 2017

1 reference