MODY: history, genetics, pathophysiology, and clinical decision making (Q35123359)

6 August 2017

4 references

13 March 2019

14 March 2019

24 March 2019

4 February 2021

MODY: history, genetics, pathophysiology, and clinical decision making (English)

1 reference

6 August 2017

1 reference

1 reference

1 reference

4 February 2021

2

Graeme I Bell

1 reference

6 August 2017

Stefan S. Fajans

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21788644

8 December 2024

language of work or name

English

0 references

publication date

1 August 2011

5 references

6 August 2017

13 March 2019

14 March 2019

24 March 2019

4 February 2021

August 2011

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21788644

full work available at URL

8 December 2024

https://doi.org/10.2337/dc11-0035

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21788644

https://europepmc.org/articles/PMC3142024

8 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21788644

https://europepmc.org/articles/PMC3142024?pdf=render

8 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21788644

https://diabetesjournals.org/care/article-pdf/34/8/1878/609775/1878.pdf

8 December 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.2337/DC11-0035

8 December 2024

5 references

6 August 2017

13 March 2019

14 March 2019

24 March 2019

4 February 2021

34

1 reference

6 August 2017

issue

8

1 reference

6 August 2017

page(s)

1878-1884

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Creative Commons Attribution-NonCommercial-NoDerivatives

6 August 2017

copyright license

4 references

13 March 2019

14 March 2019

24 March 2019

4 February 2021

on focus list of Wikimedia project

ScienceSource

0 references

cites work

Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

1 reference

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A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

28 July 2018

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Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations

28 July 2018

1 reference

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Insufficient sensitivity of hemoglobin A(₁C) determination in diagnosis or screening of early diabetic states

28 July 2018

1 reference

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Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60.

28 July 2018

1 reference

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

28 July 2018

1 reference

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Standards of medical care in diabetes--2010.

28 July 2018

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Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).

28 July 2018

1 reference

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The diagnosis and management of monogenic diabetes in children and adolescents

28 July 2018

1 reference

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Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

28 July 2018

1 reference

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Mutation in hepatocyte nuclear factor–1β gene (TCF2) associated with MODY

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Diminished Insulin and Glucagon Secretory Responses to Arginine in Nondiabetic Subjects With a Mutation in the Hepatocyte Nuclear Factor–4α/MODY1 Gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Maturity-onset diabetes of the young

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Effect of Amino Acids and Proteins on Insulin Secretion in Man

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Mild familial diabetes with dominant inheritance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Heterogeneity of insulin secretion in type II diabetes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

MODY--a model for understanding the pathogeneses and natural history of type II diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Insulin gene analysis in a family with maturity-onset diabetes of the young

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Scope and heterogeneous nature of MODY.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q

28 July 2018

1 reference

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Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

MODY: a model for the study of the molecular genetics of NIDDM.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Linkage of type 2 diabetes to the glucokinase gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

The Banting Memorial Lecture 1978. Clinical and etiologic heterogeneity of idiopathic diabetes mellitus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

DIABETES MELLITUS AND HEREDITY

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Maturity-onset diabetes of the young in children with incidental hyperglycemia: a multicenter Italian study of 172 families

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Phenotypic heterogeneity between different mutations of MODY subtypes and within MODY pedigrees

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Improved prandial glucose control with lower risk of hypoglycemia with nateglinide than with glibenclamide in patients with maturity-onset diabetes of the young type 3.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Administration of sulfonylureas can increase glucose-induced insulin secretion for decades in patients with maturity-onset diabetes of the young

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Maturity Onset-type Diabetes of the Young (MODY): One Condition or Many?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Maturity-onset diabetes of the young (MODY): how many cases are we missing?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142024

Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20

16 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Tolbutamide-induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Linkage studies of maturity onset diabetes of the young--R.W. pedigree

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Macrosomia and neonatal hypoglycaemia in RW pedigree subjects with a mutation (Q268X) in the gene encoding hepatocyte nuclear factor 4alpha (HNF4A)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

The various faces of diabetes in the young: changing concepts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

A Difference Between the Inheritance of Classical Juvenile-onset and Maturity-onset Type Diabetes of Young People

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Mutations in the hepatocyte nuclear factor-1α gene in Caucasian families originally classified as having Type I diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

The course of asymptomatic diabetes in young people, as determined by levels of blood glucose and plasma insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

An approach to the prediction of diabetes mellitus by modification of the glucose tolerance test with cortisone

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Linkage analysis of the human insulin receptor gene and maturity onset diabetes of the young

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

The early recognition of diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/21788644

12 December 2020

Identifiers

DOI

10.2337/DC11-0035

1 reference

6 August 2017

1 reference

6 August 2017

1 reference