Two EGF molecules contribute additively to stabilization of the EGFR dimer (Q33885990)

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31 October 2019

title

Two EGF molecules contribute additively to stabilization of the EGFR dimer (English)

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31 October 2019

1

1 reference

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31 October 2019

John E. Ladbury

3

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31 October 2019

8

J Schlessinger

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31 October 2019

author name string

Z Bu

2

1 reference

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31 October 2019

M Zhou

4

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31 October 2019

D Pinchasi

5

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31 October 2019

I Lax

6

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31 October 2019

D M Engelman

7

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31 October 2019

language of work or name

English

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publication date

1 January 1997

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31 October 2019

1 reference

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31 October 2019

volume

16

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31 October 2019

issue

2

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page(s)

281-294

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Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes

31 October 2019

cites work

1 reference

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Activation of epidermal growth factor receptor by epidermal growth factor

5 July 2018

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Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities

5 July 2018

1 reference

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Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta

5 July 2018

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Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?

5 July 2018

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Betacellulin: a mitogen from pancreatic beta cell tumors

5 July 2018

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Cytokine signal transduction

5 July 2018

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

5 July 2018

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The extracellular domain of the epidermal growth factor receptor. Studies on the affinity and stoichiometry of binding, receptor dimerization and a binding-domain mutant

5 July 2018

1 reference

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Dimerization of cell surface receptors in signal transduction

5 July 2018

1 reference

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The structural basis for the specificity of epidermal growth factor and heregulin binding

5 July 2018

1 reference

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Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes

5 July 2018

1 reference

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Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor

5 July 2018

1 reference

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Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor

5 July 2018

1 reference

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Binding of Neu Differentiation Factor with the Extracellular Domain of Her2 and Her3

5 July 2018

1 reference

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The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

5 July 2018

1 reference

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Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

5 July 2018

1 reference

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The epidermal growth factor receptor as a multifunctional allosteric protein

5 July 2018

1 reference

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Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling

5 July 2018

1 reference

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Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3

5 July 2018

1 reference

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Epidermal growth factor binding induces a conformational change in the external domain of its receptor

5 July 2018

1 reference

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Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation

5 July 2018

1 reference

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The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity

5 July 2018

1 reference

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The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex

5 July 2018

1 reference

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Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells

5 July 2018

1 reference

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Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

5 July 2018

1 reference

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Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

5 July 2018

1 reference

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A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

5 July 2018

1 reference

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Noncontiguous regions in the extracellular domain of EGF receptor define ligand-binding specificity

5 July 2018

1 reference

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EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.

5 July 2018

1 reference

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

5 July 2018

1 reference

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Rational design of potent antagonists to the human growth hormone receptor

5 July 2018

1 reference

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A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses

5 July 2018

1 reference

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Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses

5 July 2018

1 reference

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Growth factor signaling by receptor tyrosine kinases

5 July 2018

1 reference

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A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor

5 July 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/9029149

12 December 2020

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9029149

12 December 2020

Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9029149

12 December 2020

Immunoaffinity purification of the epidermal growth factor receptor. Stoichiometry of binding and kinetics of self-phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9029149

12 December 2020

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9029149

12 December 2020

Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9029149

12 December 2020

Three classes of epidermal growth factor receptors on HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9029149

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/16.2.281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9029149%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

1 reference

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31 October 2019

PubMed publication ID

9029149

1 reference