Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency (Q33373012)

26 July 2017

title

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency (English)

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26 July 2017

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4

Francis J Castellino

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26 July 2017

Angelina J Lay

1

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26 July 2017

Deborah Donahue

series ordinal

2

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26 July 2017

Meng-Ju Tsai

series ordinal

3

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26 July 2017

language of work or name

English

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publication date

17 October 2006

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26 July 2017

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26 July 2017

volume

109

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26 July 2017

issue

5

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26 July 2017

page(s)

1984-1991

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Human protein C and activated protein C Components of the human anticoagulation system

26 July 2017

cites work

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Effects of recombinant human activated protein C in human models of endotoxin administration

21 June 2018

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Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis

21 June 2018

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Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities

21 June 2018

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A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model

21 June 2018

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21 June 2018

Coagulation in sepsis

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Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway

21 June 2018

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Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C.

21 June 2018

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21 June 2018

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Such stuff as dreams are made on: mediator-directed therapy in sepsis

21 June 2018

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Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis

21 June 2018

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Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome

21 June 2018

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 June 2018

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Protein C levels as a prognostic indicator of outcome in sepsis and related diseases

21 June 2018

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Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice

21 June 2018

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Cellular regulation of the protein C pathway

21 June 2018

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21 June 2018

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Anticoagulant properties of bovine plasma protein C following activation by thrombin

21 June 2018

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Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

21 June 2018

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Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice.

31 October 2018

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Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei

31 October 2018

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Influence of the factor V Leiden mutation on infectious disease susceptibility and outcome: a population-based study

31 October 2018

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Hemodynamic variables related to outcome in septic shock

31 October 2018

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Factor V Leiden polymorphism modifies sepsis outcome: evidence from animal studies

31 October 2018

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Severe protein C deficiency predicts early death in severe sepsis

31 October 2018

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Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia.

31 October 2018

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Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.

31 October 2018

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Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis

31 October 2018

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Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide

31 October 2018

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A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

31 October 2018

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12 December 2020

Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

Activated protein C attenuates coagulation-associated over-expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

The interaction of activated protein C and thrombin with the plasminogen activator inhibitor released from human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment*

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

Patients with severe sepsis vary markedly in their ability to generate activated protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

Lepirudin blunts endotoxin-induced coagulation activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

Factor V Leiden and sepsis: Proof positive or phenomenology?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17047151

12 December 2020

10.1182/BLOOD-2006-07-037945

Identifiers

DOI

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26 July 2017

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26 July 2017

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