Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure (Q28512661)

25 January 2017

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28 December 2019

title

Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure (English)

2 references

25 January 2017

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Growth arrest and DNA-damage-inducible 45 alpha

28 December 2019

main subject

1 reference

Breast cancer 1, early onset

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Albert J Fornace

6

1 reference

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28 December 2019

author name string

Xiaoyan Wang

1

2 references

25 January 2017

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28 December 2019

Rui-Hong Wang

2

2 references

25 January 2017

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28 December 2019

Wenmei Li

3

2 references

25 January 2017

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28 December 2019

Xiaoling Xu

4

2 references

25 January 2017

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28 December 2019

Chu-Xia Deng

7

2 references

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28 December 2019

M Christine Hollander

5

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28 December 2019

language of work or name

English

0 references

publication date

3 May 2004

1 reference

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Journal of Biological Chemistry

28 December 2019

published in

2 references

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28 December 2019

volume

279

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28 December 2019

issue

28

2 references

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28 December 2019

page(s)

29606-29614

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Keeping the centrosome cycle on track. Genome stability

28 December 2019

cites work

1 reference

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The centrosome in vertebrates: more than a microtubule-organizing center

21 January 2018

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Integration of the centrosome in cell cycle control, stress response and signal transduction pathways

21 January 2018

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Centrosome amplification drives chromosomal instability in breast tumor development

21 January 2018

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

1 reference

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A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

21 January 2018

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

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Lessons learned from BRCA1 and BRCA2.

21 January 2018

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Roles of BRCA1 in DNA damage repair: a link between development and cancer

21 January 2018

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Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

21 January 2018

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 January 2018

1 reference

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Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

21 January 2018

1 reference

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

1 reference

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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

21 January 2018

1 reference

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Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

21 January 2018

1 reference

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

21 January 2018

1 reference

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

1 reference

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Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

21 January 2018

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

1 reference

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

21 January 2018

1 reference

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

21 January 2018

1 reference

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Role of Gadd45 in apoptosis

21 January 2018

1 reference

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Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin

21 January 2018

1 reference

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GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

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BRCA1 activation of the GADD45 promoter.

21 January 2018

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p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

21 January 2018

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Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a

21 January 2018

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Oligomerization of human Gadd45a protein

21 January 2018

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Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis

21 January 2018

1 reference

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.

21 January 2018

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The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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The Nek2 protein kinase: a novel regulator of centrosome structure

21 January 2018

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Epidemiologic characteristics of phenotypically distinct neural tube defects among 0.7 million California births, 1983-1987.

21 January 2018

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The embryonic development of mammalian neural tube defects.

21 January 2018

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Mouse models for neural tube closure defects

21 January 2018

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A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

21 January 2018

1 reference

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Roles of BRCA1 in centrosome duplication

21 January 2018

1 reference

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BRCA1 is associated with the centrosome during mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312279200

21 January 2018

Identifiers

DOI

10.1074/JBC.M312279200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15123655%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

2 references

25 January 2017