The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer (Q28261714)

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25 January 2020

title

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer (English)

1 reference

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25 January 2020

1 reference

1

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25 January 2020

Pol Gimenez Xavier

4

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25 January 2020

Gonzalo Gómez-López

5

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25 January 2020

David G. Pisano

6

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25 January 2020

Montse Sanchez-Cespedes

10

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25 January 2020

9

Gordon L Hager

1 reference

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25 January 2020

author name string

Fernando Setien

2

1 reference

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25 January 2020

Sam John

3

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25 January 2020

Enric Condom

7

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25 January 2020

Alberto Villanueva

8

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language of work or name

English

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publication date

11 April 2012

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25 January 2020

published in

EMBO Molecular Medicine

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25 January 2020

volume

4

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25 January 2020

issue

7

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page(s)

603-616

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Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer

25 January 2020

cites work

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Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

20 March 2017

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The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor

20 March 2017

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mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad

20 March 2017

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BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation

20 March 2017

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The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton

20 March 2017

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Genomic targets of the human c-Myc protein

20 March 2017

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Chromatin remodeling: nucleosomes bulging at the seams

20 March 2017

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Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells

20 March 2017

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Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation

20 March 2017

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BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines

20 March 2017

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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

20 March 2017

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Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

20 March 2017

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Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor

20 March 2017

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Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement

20 March 2017

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Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation

20 March 2017

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Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex

20 March 2017

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Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

20 March 2017

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BRG1 mutations found in human cancer cell lines inactivate Rb-mediated cell-cycle arrest

29 September 2017

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29 September 2017

PAI-1 in tissue fibrosis

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Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches

29 September 2017

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A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer

29 September 2017

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Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors

29 September 2017

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Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements

29 September 2017

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Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

29 September 2017

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Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming

29 September 2017

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Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease

29 September 2017

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Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter

29 September 2017

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Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification

29 September 2017

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Combinational treatment with retinoic acid derivatives in non-small cell lung carcinoma in vitro

29 September 2017

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Unwinding chromatin for development and growth: a few genes at a time.

29 September 2017

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BRG1 loss in MiaPaCa2 cells induces an altered cellular morphology and disruption in the organization of the actin cytoskeleton

29 September 2017

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Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.

29 September 2017

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The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.

29 September 2017

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Analysis of co-factor function in a glucocorticoid-resistant small cell carcinoma cell line.

29 September 2017

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Rapid periodic binding and displacement of the glucocorticoid receptor during chromatin remodeling

29 September 2017

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Role for BRG1 in cell cycle control and tumor suppression

29 September 2017

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Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent

29 September 2017

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The AF-1 and AF-2 activating domains of retinoic acid receptor-alpha (RARalpha) and their phosphorylation are differentially involved in parietal endodermal differentiation of F9 cells and retinoid-induced expression of target genes

29 September 2017

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Regulation of retinoic acid signaling during lung morphogenesis

29 September 2017

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The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter

29 September 2017

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Retinoid refractoriness occurs during lung carcinogenesis despite functional retinoid receptors

29 September 2017

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The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression

29 September 2017

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The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest

2 June 2018

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Human lung cancer cell lines exhibit resistance to retinoic acid treatment.

2 June 2018

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Differentiation of human variant small cell lung cancer cell lines to a classic morphology by retinoic acid.

2 June 2018

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Characterization of mammary tumors from Brg1 heterozygous mice.

2 June 2018

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Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development

21 January 2018

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Altered epithelial cell proportions in the fetal lung of glucocorticoid receptor null mice.

21 January 2018

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Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway.

21 January 2018

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Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22407764

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12 December 2020

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Experimental cancer of the lung.Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors

1 reference

PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation

1 reference

PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/EMMM.201200236

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22407764%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

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25 January 2020

PubMed publication ID

22407764

1 reference

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