The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway (Q28117215)

4 January 2017

title

The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway (English)

1 reference

4 January 2017

main subject

HtrA serine peptidase 2

1 reference

PPARG coactivator 1 alpha

1 reference

glycogen synthase kinase 3 beta

1 reference

positive regulation of mitochondrion organization

1 reference

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

R Xu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Q Hu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Q Ma

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

G Wang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

publication date

14 August 2014

1 reference

4 January 2017

published in

Cell Death and Disease

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

5

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

e1373

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

3 June 2020

copyright license

start time

1 August 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi

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SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

20 March 2017

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

20 March 2017

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

20 March 2017

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The dynamics of the mitochondrial organelle as a potential therapeutic target

20 March 2017

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PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling

20 March 2017

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GSK3B polymorphisms alter transcription and splicing in Parkinson's disease

20 March 2017

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

20 March 2017

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Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

20 March 2017

1 reference

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

20 March 2017

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

20 March 2017

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

20 March 2017

1 reference

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Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

20 March 2017

1 reference

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Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease

20 March 2017

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

20 March 2017

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 April 2017

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

7 April 2017

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Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

7 April 2017

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The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation.

29 September 2017

1 reference

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Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation

29 September 2017

1 reference

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The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's disease

29 September 2017

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GSK-3 in Neurodegenerative Diseases.

29 September 2017

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Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease

29 September 2017

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Preclinical biomarkers of Parkinson disease

29 September 2017

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Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

29 September 2017

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Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

29 September 2017

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Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinson's disease.

29 September 2017

1 reference

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Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships

29 September 2017

1 reference

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Regulation of neuron mitochondrial biogenesis and relevance to brain health

29 September 2017

1 reference

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Transcriptional control of mitochondrial biogenesis and function

29 September 2017

1 reference

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The biology of PGC-1α and its therapeutic potential

29 September 2017

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Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454303

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha.

29 September 2017

1 reference

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Mitochondrial biogenesis and turnover

29 September 2017

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Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454303

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454303

Transgenic mice with neuron-specific overexpression of HtrA2/Omi suggest a neuroprotective role for HtrA2/Omi

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454303

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

29 September 2017

1 reference

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Expanding insights of mitochondrial dysfunction in Parkinson's disease.

29 September 2017

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Parkin enhances mitochondrial biogenesis in proliferating cells

29 September 2017

1 reference

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

29 September 2017

1 reference

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Mitochondria and neuronal survival

29 September 2017

1 reference

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Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454303

Progressive loss of striatal neurons causes motor dysfunction in MND2 mutant mice and is not prevented by Bcl-2.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4454303

Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.328

Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.328

Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.328

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.328

Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.328

Peripheral expression of key regulatory kinases in Alzheimer's disease and Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.328

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2014.328

Rosiglitazone induces mitochondrial biogenesis in mouse brain.

21 January 2018

1 reference

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Alteration of mtDNA copy number, mitochondrial gene expression and extracellular DNA content in mice after irradiation at lethal dose

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25118933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2014.328

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

2 references

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3 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118933%20AND%20SRC:MED&resulttype=core&format=json