MicroRNA let-7: an emerging next-generation cancer therapeutic (Q24644251)

April 2022 Public Data File from Crossref

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Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression

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Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression

7 April 2017

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Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

7 April 2017

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Enjoy the Silence: The Story of let-7 MicroRNA and Cancer

7 April 2017

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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

7 April 2017

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Temporal regulation of metamorphic processes in Drosophila by the let-7 and miR-125 heterochronic microRNAs

7 April 2017

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Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

7 April 2017

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Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis

7 April 2017

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Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence

7 April 2017

1 reference

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MicroRNA regulation of cell lineages in mouse and human embryonic stem cells

7 April 2017

1 reference

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Suppression of non-small cell lung tumor development by the let-7 microRNA family

7 April 2017

1 reference

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Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin

7 April 2017

1 reference

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Selective blockade of microRNA processing by Lin28

7 April 2017

1 reference

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Oct4 expression is not required for mouse somatic stem cell self-renewal

7 April 2017

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Widespread microRNA repression by Myc contributes to tumorigenesis

7 April 2017

1 reference

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miRGator: an integrated system for functional annotation of microRNAs

7 April 2017

1 reference

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MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt

7 April 2017

1 reference

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Let-7 expression defines two differentiation stages of cancer

7 April 2017

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Requirement of bic/microRNA-155 for normal immune function

7 April 2017

1 reference

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The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

7 April 2017

1 reference

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Improved targeting of miRNA with antisense oligonucleotides

7 April 2017

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Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155.

7 April 2017

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The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

7 April 2017

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Real-time expression profiling of microRNA precursors in human cancer cell lines

7 April 2017

1 reference

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An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi

7 April 2017

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Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

7 April 2017

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The transcriptome profile of human embryonic stem cells as defined by SAGE

7 April 2017

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A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development

7 April 2017

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Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

7 April 2017

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Silencing of microRNAs in vivo with 'antagomirs'

7 April 2017

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RAS is regulated by the let-7 microRNA family

7 April 2017

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MicroRNAs modulate hematopoietic lineage differentiation

7 April 2017

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A system for stable expression of short interfering RNAs in mammalian cells

7 April 2017

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

7 April 2017

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

7 April 2017

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Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family

7 April 2017

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Identification of let-7-regulated oncofetal genes

7 April 2017

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Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma

7 April 2017

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Do cells let-7 determine stemness?

7 April 2017

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The let-7 microRNA reduces tumor growth in mouse models of lung cancer

7 April 2017

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Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer

7 April 2017

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let-7 regulates self renewal and tumorigenicity of breast cancer cells

7 April 2017

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Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2

7 April 2017

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let-7 microRNA expression is reduced in bronchioloalveolar carcinoma, a non-invasive carcinoma, and is not correlated with prognosis

7 April 2017

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The let-7 microRNA represses cell proliferation pathways in human cells

7 April 2017

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Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis

7 April 2017

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Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2

7 April 2017

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Post-transcriptional regulation of the let-7 microRNA during neural cell specification

7 April 2017

1 reference

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MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

let-7 microRNA functions as a potential growth suppressor in human colon cancer cells

7 April 2017

1 reference

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Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

MicroRNA expression in zebrafish embryonic development

7 April 2017

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CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells

7 April 2017

1 reference

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The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins

7 April 2017

1 reference

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Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Reduced accumulation of specific microRNAs in colorectal neoplasia

7 April 2017

1 reference

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Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

7 April 2017

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Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Cancer stem cells: models and concepts

7 April 2017

1 reference

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Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation

7 April 2017

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Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3.

27 September 2017

1 reference

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MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries

27 September 2017

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A matter of timing: microRNA-controlled temporal identities in worms and flies

27 September 2017

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Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts

27 September 2017

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MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution

27 September 2017

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Why myc? An unexpected ingredient in the stem cell cocktail

27 September 2017

1 reference

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Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein

27 September 2017

1 reference

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The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

27 September 2017

1 reference

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Construction and identification of a human liver specific microRNA eukaryotic expression vector.

27 September 2017

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A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells

27 September 2017

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MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia

27 September 2017

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MicroRNAs in disease and potential therapeutic applications

27 September 2017

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The biology of cancer stem cells

27 September 2017

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Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

miRNAs in cancer: approaches, aetiology, diagnostics and therapy

27 September 2017

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Detection of let-7a microRNA by real-time PCR in gastric carcinoma.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Therapeutic potential for microRNAs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Specificity, duplex degradation and subcellular localization of antagomirs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

MicroRNAs play an essential role in the development of cardiac hypertrophy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Murine microRNAs implicated in liver functions and aging process.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Increased expression of high mobility group A proteins in lung cancer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

LNA-modified oligonucleotides mediate specific inhibition of microRNA function.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Spatial differences in hematopoiesis but not in stem cells indicate a lack of regional patterning in definitive hematopoietic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Use of RNA polymerase II to transcribe artificial microRNAs.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826782

Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20179807

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Detection of let-7a microRNA by real-time PCR in colorectal cancer: a single-centre experience from China

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20179807

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20179807

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3747/CO.V17I1.356

1 reference

1 reference

1 reference

PubMed publication ID

20179807

1 reference