SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair (Q24541386)

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15 January 2020

title

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair (English)

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15 January 2020

1

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15 January 2020

author name string

Cristina Rada

series ordinal

2

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15 January 2020

Michael S Neuberger

series ordinal

3

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language of work or name

English

0 references

publication date

12 January 2006

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15 January 2020

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15 January 2020

volume

25

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issue

3

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15 January 2020

page(s)

585-595

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hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

15 January 2020

cites work

1 reference

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Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

24 March 2017

1 reference

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Post-replicative base excision repair in replication foci

24 March 2017

1 reference

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Immunity through DNA deamination

24 March 2017

1 reference

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The nature of enzymes involved in uracil-DNA repair: isoform characteristics of proteins responsible for nuclear and mitochondrial genomic integrity

24 March 2017

1 reference

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Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

24 March 2017

1 reference

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Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

24 March 2017

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

24 March 2017

1 reference

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B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases

27 September 2017

1 reference

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Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

27 September 2017

1 reference

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Uracil in DNA--occurrence, consequences and repair

27 September 2017

1 reference

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Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

AID is essential for immunoglobulin V gene conversion in a cultured B cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice

27 September 2017

1 reference

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Uracil-DNA glycosylase inhibitor of bacteriophage PBS2: cloning and effects of expression of the inhibitor gene in Escherichia coli

27 September 2017

1 reference

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Light chain gene conversion continues at high rate in an ALV-induced cell line.

27 September 2017

1 reference

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A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine

27 September 2017

1 reference

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N-Glycosidase activity in extracts of Bacillus subtilis and its inhibition after infection with bacteriophage PBS2.

27 September 2017

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

27 September 2017

1 reference

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Proteolytic degradation of the nuclear isoform of uracil-DNA glycosylase occurs during the S phase of the cell cycle

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1383525

29 November 2018

Identifiers

DOI

10.1038/SJ.EMBOJ.7600939

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407970%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

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15 January 2020

PubMed publication ID

16407970

1 reference