The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO (Q24336822)

receptor interacting serine/threonine kinase 2

1 reference

positive regulation of NF-kappaB transcription factor activity

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Nucleotide-binding oligomerization domain containing 2

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Activation of nuclear factor kappa B in Crohn's disease

Derek W Abbott

1

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Lewis C. Cantley

object named as

Lewis C Cantley

series ordinal

4

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John M Asara

series ordinal

3

object named as

John M Asara

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author name string

Andrew Wilkins

series ordinal

2

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language of work or name

English

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publication date

29 December 2004

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published in

Current Biology

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volume

14

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issue

24

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page(s)

2217-27

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cites work

1 reference

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

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Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

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Autoimmunity and apoptosis: the Crohn's connection

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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Identification of the familial cylindromatosis tumour-suppressor gene

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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A proteomics approach to understanding protein ubiquitination

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Intracellular debugging

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How NOD-ing off leads to Crohn disease

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

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The immunological and genetic basis of inflammatory bowel disease

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Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

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Inflammatory Bowel Disease

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Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

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Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis

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RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis

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RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

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Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation.

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

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Human Nod1 confers responsiveness to bacterial lipopolysaccharides

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Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

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A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

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Non-traditional functions of ubiquitin and ubiquitin-binding proteins

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BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

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10.1016/J.CUB.2004.12.032

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

release_pkmo2g5owreyxiwi5ioyy3fmqu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pkmo2g5owreyxiwi5ioyy3fmqu

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15620648

1 reference

Consolidated OpenCitations Corpus – April 2017