Proprotein convertase subtilisin/kexin type 9 (Q21130010)

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mammalian protein found in Homo sapiens
  • proprotein convertase subtilisin/kexin type 9
  • subtilisin/kexin-like protease PC9
  • neural apoptosis regulated convertase 1
  • PCSK9
  • PC9
  • convertase subtilisin/kexin type 9 preproprotein
  • NARC-1
  • Proprotein convertase 9
  • Neural apoptosis-regulated convertase 1
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Language Label Description Also known as
English
Proprotein convertase subtilisin/kexin type 9
mammalian protein found in Homo sapiens
  • proprotein convertase subtilisin/kexin type 9
  • subtilisin/kexin-like protease PC9
  • neural apoptosis regulated convertase 1
  • PCSK9
  • PC9
  • convertase subtilisin/kexin type 9 preproprotein
  • NARC-1
  • Proprotein convertase 9
  • Neural apoptosis-regulated convertase 1

Statements

molecular function
protein binding
determination method or standard
IPI
7 references
retrieved
8 April 2019
stated in
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR
GOA
curator
UniProt
UniProt protein ID
Q8NBP7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)
GOA
curator
UniProt
UniProt protein ID
Q8NBP7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor
GOA
curator
UniProt
UniProt protein ID
Q8NBP7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IPI
retrieved
8 April 2019
stated in
MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IPI
cell component
extracellular space
determination method or standard
IBA
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IEA
retrieved
8 April 2019
stated in
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7
determination method or standard
IBA
biological process
Commons category
PCSK9
0 references

Identifiers

MeSH descriptor ID
D000071449
subject named as
Proprotein Convertase 9
0 references
Freebase ID
/m/03cwp97
0 references
PDB structure ID
 
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