A guide to genome engineering with programmable nucleases (Q38201212)

30 August 2017

title

A guide to genome engineering with programmable nucleases (English)

1 reference

30 August 2017

Hyongbum Kim

1

1 reference

30 August 2017

Jin-Soo Kim

series ordinal

2

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30 August 2017

publication date

2 April 2014

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30 August 2017

published in

Nature Reviews Genetics

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30 August 2017

volume

15

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30 August 2017

issue

5

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30 August 2017

page(s)

321-334

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Insights into effective RNAi gained from large-scale siRNA validation screening

30 August 2017

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In vivo genome editing restores haemostasis in a mouse model of haemophilia

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Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

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Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.

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Genome engineering at the dawn of the golden age.

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Advances in targeted genome editing

21 January 2018

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21 January 2018

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21 January 2018

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Genome editing with modularly assembled zinc-finger nucleases

21 January 2018

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Unexpected failure rates for modular assembly of engineered zinc fingers

21 January 2018

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DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases

21 January 2018

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Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

21 January 2018

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Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

21 January 2018

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An optimized two-finger archive for ZFN-mediated gene targeting

21 January 2018

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Highly active zinc-finger nucleases by extended modular assembly

21 January 2018

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Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

21 January 2018

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Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly

21 January 2018

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Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases.

21 January 2018

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TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

21 January 2018

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Targeting DNA double-strand breaks with TAL effector nucleases

21 January 2018

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Knockout rats generated by embryo microinjection of TALENs.

21 January 2018

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Transcription activator-like effector nucleases (TALENs): a highly efficient and versatile tool for genome editing

21 January 2018

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TALENs: a widely applicable technology for targeted genome editing

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A TALE nuclease architecture for efficient genome editing

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Characterization and DNA-binding specificities of Ralstonia TAL-like effectors

21 January 2018

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TAL effector specificity for base 0 of the DNA target is altered in a complex, effector- and assay-dependent manner by substitutions for the tryptophan in cryptic repeat -1.

21 January 2018

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The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

21 January 2018

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Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

21 January 2018

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Breaking the code of DNA binding specificity of TAL-type III effectors

21 January 2018

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A simple cipher governs DNA recognition by TAL effectors

21 January 2018

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E-TALEN: a web tool to design TALENs for genome engineering.

21 January 2018

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Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.

21 January 2018

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Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

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FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

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A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

21 January 2018

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Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers

21 January 2018

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21 January 2018

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TALEN-based knockout library for human microRNAs

21 January 2018

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An integrated chip for the high-throughput synthesis of transcription activator-like effectors.

21 January 2018

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Directed evolution of the TALE N-terminal domain for recognition of all 5' bases.

21 January 2018

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Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease.

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Recognition of methylated DNA by TAL effectors

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Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9.

21 January 2018

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Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease

21 January 2018

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Targeted genome modification of crop plants using a CRISPR-Cas system.

21 January 2018

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Heritable genome editing in C. elegans via a CRISPR-Cas9 system

21 January 2018

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Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination

21 January 2018

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Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins

21 January 2018

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Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.

21 January 2018

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Heritable gene targeting in the mouse and rat using a CRISPR-Cas system.

21 January 2018

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Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases

21 January 2018

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Generation of gene-modified mice via Cas9/RNA-mediated gene targeting

21 January 2018

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Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems.

21 January 2018

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Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

21 January 2018

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Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs

21 January 2018

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A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

21 January 2018

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CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

21 January 2018

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CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

21 January 2018

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DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

21 January 2018

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Short motif sequences determine the targets of the prokaryotic CRISPR defence system

21 January 2018

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DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

21 January 2018

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Protospacer recognition motifs: mixed identities and functional diversity

21 January 2018

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Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

21 January 2018

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Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems

21 January 2018

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

21 January 2018

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Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

21 January 2018

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A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

21 January 2018

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An unbiased genome-wide analysis of zinc-finger nuclease specificity

21 January 2018

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

21 January 2018

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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

21 January 2018

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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

21 January 2018

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Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.

21 January 2018

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TALENs and ZFNs are associated with different mutation signatures

21 January 2018

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

21 January 2018

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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

21 January 2018

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Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

21 January 2018

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Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

21 January 2018

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Genome-scale CRISPR-Cas9 knockout screening in human cells

21 January 2018

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Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

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21 January 2018

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Receptor-mediated delivery of engineered nucleases for genome modification

21 January 2018

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Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG3686

Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

E-CRISP: fast CRISPR target site identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

DNA nicks promote efficient and safe targeted gene correction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Precision genome engineering with programmable DNA-nicking enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Transient cold shock enhances zinc-finger nuclease-mediated gene disruption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Stability of zinc finger nuclease protein is enhanced by the proteasome inhibitor MG132.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

p53 Gene repair with zinc finger nucleases optimised by yeast 1-hybrid and validated by Solexa sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Coupling endonucleases with DNA end-processing enzymes to drive gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Surrogate reporters for enrichment of cells with nuclease-induced mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Magnetic separation and antibiotics selection enable enrichment of cells with ZFN/TALEN-induced mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Tracking genome engineering outcome at individual DNA breakpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Positive and negative regulation of endogenous genes by designed transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Locus-specific editing of histone modifications at endogenous enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Optical control of mammalian endogenous transcription and epigenetic states

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Vigilance and validation: Keys to success in RNAi screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Increasing cloning possibilities using artificial zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeted mutagenesis in the malaria mosquito using TALE nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeted genome modification in mice using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Knockout rats via embryo microinjection of zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

High-frequency modification of plant genes using engineered zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

High-efficiency TALEN-based gene editing produces disease-resistant rice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

TALEN-based gene correction for epidermolysis bullosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Translating dosage compensation to trisomy 21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Genome Engineering With Zinc-Finger Nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Expressing the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Knockout mice created by TALEN-mediated gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Genotyping with CRISPR-Cas-derived RNA-guided endonucleases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Live visualization of chromatin dynamics with fluorescent TALEs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Preassembled zinc-finger arrays for rapid construction of ZFNs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG3686

Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24690881

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3686

1 reference

Dimensions Publication ID

30 August 2017

1016455001

0 references

1 reference