Mitochondria, calcium and cell death: a deadly triad in neurodegeneration (Q24646020)

Europe PubMed Central

title

Mitochondria, calcium and cell death: a deadly triad in neurodegeneration (English)

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Carmen Fotino

5

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Fulvio Celsi

Fulvio Celsi

1

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Paola Pizzo

Paola Pizzo

2

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Marisa Brini

Marisa Brini

3

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Rosario Rizzuto

Rosario Rizzuto

7

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Paolo Pinton

Paolo Pinton

6

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author name string

Sara Leo

Biochimica et Biophysica Acta

4

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language of work or name

English

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publication date

May 2009

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published in

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volume

1787

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issue

5

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page(s)

335-44

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cites work

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Innovation: Looking forward to seeing calcium

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

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Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux

7 April 2017

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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

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N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

27 September 2017

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27 September 2017

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Mitochondrial Ca2+ and the heart

27 September 2017

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Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease

27 September 2017

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27 September 2017

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27 September 2017

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Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease

27 September 2017

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27 September 2017

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

27 September 2017

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Calcium and neurodegeneration

27 September 2017

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

27 September 2017

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Parkin and defective ubiquitination in Parkinson's disease

27 September 2017

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Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

27 September 2017

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Mitochondrial alterations in Alzheimer's disease

27 September 2017

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Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

27 September 2017

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Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

27 September 2017

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3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

27 September 2017

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Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals

27 September 2017

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Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.

27 September 2017

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Deranged neuronal calcium signaling and Huntington disease.

27 September 2017

1 reference

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Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

27 September 2017

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

27 September 2017

1 reference

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The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores

27 September 2017

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Historical review: mitochondria and calcium: ups and downs of an unusual relationship

27 September 2017

1 reference

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

27 September 2017

1 reference

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Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

27 September 2017

1 reference

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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

27 September 2017

1 reference

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Complex I and Parkinson's disease

27 September 2017

1 reference

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Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming

27 September 2017

1 reference

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A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency

27 September 2017

1 reference

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Impact of mitochondrial Ca2+ cycling on pattern formation and stability

27 September 2017

1 reference

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Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes

27 September 2017

1 reference

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Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence

27 September 2017

1 reference

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New light on mitochondrial calcium

27 September 2017

1 reference

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Ca2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured In situ in intact cells.

27 September 2017

1 reference

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Evidence that mitochondria buffer physiological Ca2+ loads in lizard motor nerve terminals

27 September 2017

1 reference

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Imaging the permeability pore transition in single mitochondria

27 September 2017

1 reference

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Mitochondrial participation in the intracellular Ca2+ network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Targeting aequorin and green fluorescent protein to intracellular organelles

27 September 2017

1 reference

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Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na(+)-Ca2+ exchange

27 September 2017

1 reference

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Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

27 September 2017

1 reference

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Ca2+ as a second messenger within mitochondria of the heart and other tissues

27 September 2017

1 reference

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Kinetics of calcium(2+) ion carrier in rat liver mitochondria

27 September 2017

1 reference

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

27 September 2017

1 reference

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The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal

27 September 2017

1 reference

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Presenilins and Alzheimer disease: the calcium conspiracy.

27 September 2017

1 reference

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Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

30 May 2018

1 reference

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Apoptosis driven by IP(3)-linked mitochondrial calcium signals

30 May 2018

1 reference

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Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

30 May 2018

1 reference

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Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals.

30 May 2018

1 reference

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Integrating cytosolic calcium signals into mitochondrial metabolic responses

30 May 2018

1 reference

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Huntingtin localization in brains of normal and Huntington's disease patients

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Cytochrome oxidase deficiency in Alzheimer's disease.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Chronic exposure to sub-lethal beta-amyloid (Abeta) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

The mitochondrial calcium uniporter is a highly selective ion channel.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Oxidative damage is the earliest event in Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696196

Kinetics of mitochondrial calcium transport. II. A kinetic description of the sodium-dependent calcium efflux mechanism of liver mitochondria and inhibition by ruthenium red and by tetraphenylphosphonium

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19268425

12 December 2020

VOLUME CHANGES INDUCED BY INORGANIC PHOSPHATE IN LIVER MITOCHONDRIA

1 reference

https://pubmed.ncbi.nlm.nih.gov/19268425

12 December 2020

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19268425

12 December 2020

Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19268425

12 December 2020

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19268425

12 December 2020

Control of InsP3-induced Ca2+ oscillations in permeabilized blowfly salivary gland cells: contribution of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19268425

12 December 2020

Regulation of Ca2+ Efflux in Rat Liver Mitochondria. Role of Membrane Potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/19268425

12 December 2020

10.1016/J.BBABIO.2009.02.021

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

19268425

1 reference