Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon (Q24290775)

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3 November 2019

title

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon (English)

1 reference

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UPF3B regulator of nonsense mediated mRNA decay

3 November 2019

main subject

1 reference

UPF3A regulator of nonsense mediated mRNA decay

GOA release 2020-03-11

1 reference

structural constituent of nuclear pore

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Jens Lykke-Andersen

series ordinal

1

1 reference

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3 November 2019

3

J A Steitz

1 reference

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3 November 2019

author name string

M D Shu

series ordinal

2

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3 November 2019

language of work or name

English

0 references

publication date

1 December 2000

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3 November 2019

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3 November 2019

volume

103

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3 November 2019

issue

7

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3 November 2019

page(s)

1121-1131

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Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

3 November 2019

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The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm

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Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay

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Nonsense mutations in the human beta-globin gene affect mRNA metabolism

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An essential component of the decapping enzyme required for normal rates of mRNA turnover

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7 January 2021

Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping

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7 January 2021

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

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Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

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A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro

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Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

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Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance

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Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon

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RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

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7 January 2021

The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif

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7 January 2021

Determination of mRNA fate by different RNA polymerase II promoters

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Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs

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Nonsense-mediated mRNA decay in health and disease

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HuR binding to cytoplasmic mRNA is perturbed by heat shock

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7 January 2021

The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay

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7 January 2021

Modification of acidic residues normalizes sodium dodecyl sulfate-polyacrylamide gel electrophoresis of caldesmon and other proteins that migrate anomalously

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7 January 2021

Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover

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7 January 2021

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

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7 January 2021

Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway

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7 January 2021

A perfect message: RNA surveillance and nonsense-mediated decay

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7 January 2021

Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae

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7 January 2021

mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

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Mechanisms of mRNA surveillance in eukaryotes

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7 January 2021

Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells

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Probing the structure of HIV-1 Rev by protein footprinting of multiple monoclonal antibody-binding sites

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7 January 2021

Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm

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7 January 2021

Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA.

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Mutants of the bacteriophage MS2 coat protein that alter its cooperative binding to RNA.

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Identification of an additional gene required for eukaryotic nonsense mRNA turnover

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

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Gene products that promote mRNA turnover in Saccharomyces cerevisiae

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Nonsense surveillance in lymphocytes?

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7 January 2021

Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p

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7 January 2021

The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes

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7 January 2021

Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

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7 January 2021

Premature translational termination triggers mRNA decapping

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7 January 2021

A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

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7 January 2021

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

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7 January 2021

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor

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7 January 2021

Mammalian orthologues of a yeast regulator of nonsense transcript stability

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Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

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Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay

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mRNA surveillance by the Caenorhabditis elegans smg genes

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Messenger RNA degradation in eukaryotes

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A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells

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Molecular basis for dominantly inherited inclusion body beta-thalassemia

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Binary specification of nonsense codons by splicing and cytoplasmic translation

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Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover

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Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

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Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

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At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation

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Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

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7 January 2021

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

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3 November 2019

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017