Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice (Q42840040)

8 November 2017

Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice (English)

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8 November 2017

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van de Loo FA

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8 November 2017

Kuiper S

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8 November 2017

van Enckevort FH

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8 November 2017

Arntz OJ

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8 November 2017

van den Berg WB

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8 November 2017

language of work or name

English

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publication date

1 July 1997

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The American Journal of Pathology

8 November 2017

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8 November 2017

151

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8 November 2017

1

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8 November 2017

177-191

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The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee

8 November 2017

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The biological effects of interleukin 6.

27 May 2018

1 reference

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Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

The role of interleukin-6 in mucosal IgA antibody responses in vivo

27 May 2018

1 reference

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Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

27 May 2018

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In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Defective inflammatory response in interleukin 6-deficient mice

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interleukin-6 in relation to other proinflammatory cytokines, chemotactic activity and neutrophil activation in rheumatoid synovial fluid

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Role of interleukin 1 in antigen-induced exacerbations of murine arthritis.

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Suppression of arthritis by an inhibitor of nitric oxide synthase

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Clinical significance of interleukin-6 measurement in early rheumatoid arthritis: relation with laboratory and clinical variables and radiological progression in a three year prospective study

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Role of nitric oxide in autoimmunity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Response of interleukin‐6‐deficient mice to tumor necrosis factor‐induced metabolic changes and lethality

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orall

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Effects of experimental joint inflammation on bone marrow and periarticular bone. A study of two types of arthritis, using variable degrees of inflammation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interleukin-6 in synovial fluid from patients with arthritis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interleukin-1 beta induces synthesis and secretion of interleukin-6 in human chondrocytes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF).

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interleukin-6: historical background, genetics and biological significance

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Degenerative knee joint lesions in mice after a single intra-articular collagenase injection. A new model of osteoarthritis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF-beta.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Relationships between local inflammation, interleukin-6 concentration and the acute phase protein response in arthritis patients

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interleukin-6 and the acute phase response

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Production and modulation of interleukin 6 synthesis by synoviocytes derived from patients with arthritic disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

In situ hybridization of IL-6 in rheumatoid arthritis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Interleukin-6 and its receptor: a paradigm for cytokines

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Chronic stimulation of the pituitary-adrenal axis in rats by interleukin-1 beta infusion: in vivo and in vitro studies

27 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Zymosan-induced arthritis: a model of chronic proliferative arthritis following activation of the alternative pathway of complement

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

IL-1 beta and IL-6 selectively induce transforming growth factor-beta isoforms in human articular chondrocytes.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

The impact of protein size and charge on its retention in articular cartilage

16 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1857913

Tumour necrosis factor alpha (TNF-alpha) and interleukin 6 in a zymosan-induced shock model

16 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection

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https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes

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https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Quantitation of glycosaminoglycan metabolism in anatomically intact articular cartilage of the mouse patella: in vitro and in vivo studies with 35S-sulfate, 3H-glucosamine, and 3H-acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

A simple sensitive bioassay for interleukin-1 which is unresponsive to 10(3) U/ml of interleukin-2

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https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Inhibitory effects of interleukin 6 on immunity. Possible implications in burn patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Inhibitory role of interleukin-6 in macrophage proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. I. Development and initial characterisation of the model

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/9212744

1 reference

12 December 2020

Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Recombinant bone morphogenetic protein-4, transforming growth factor-beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

The acute phase response

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https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Measurement of interleukin-1 liberation in zymosan air-pouch exudate in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Establishment of the role of IL-6 and TNF receptor 1 using gene knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Interleukin-4, an inhibitor of cartilage breakdown in bovine articular cartilage explants

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Stimulation of TIMP-1 production by oncostatin M in human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Correlation of synovial fluid interleukin 6 (IL-6) activities with IgG concentrations in patients with inflammatory joint disease and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9212744

12 December 2020

Identifiers

1 reference

8 November 2017

PubMed publication ID

9212744

1 reference