Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia (Q34453896)

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Language	Label	Description	Also known as
English	Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

autosomal dominant hypocalcemia

1 reference

based on heuristic

inferred from title

Christof Schöfl

8

object named as

Christof Schöfl

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object named as

Bernhard Mayr

7

0 references

Benjamin Hofner

object named as

Benjamin Hofner

6

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author name string

Saskia Letz

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Christine Haag

2

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Europe PubMed Central

PubMed publication ID

2 August 2017

Egbert Schulze

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Karin Frank-Raue

4

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Europe PubMed Central

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2 August 2017

Friedhelm Raue

5

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Europe PubMed Central

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2 August 2017

language of work or name

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publication date

15 December 2014

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Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

9

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Europe PubMed Central

PubMed publication ID

2 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

e115178

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution 4.0 International

15 December 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women

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Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations

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6 July 2018

Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators

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6 July 2018

The calcium-sensing receptor and related diseases

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6 July 2018

Autosomal dominant hypocalcemia with mild type 5 Bartter syndrome

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6 July 2018

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.

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6 July 2018

Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor.

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6 July 2018

Extracellular calcium sensing and signalling

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6 July 2018

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.

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Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats

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6 July 2018

A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor

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Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

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Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation

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Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey

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Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914.

1 reference

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Activating mutations of the calcium-sensing receptor: management of hypocalcemia

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Functional Characterization of a Calcium-Sensing Receptor Mutation in Severe Autosomal Dominant Hypocalcemia with a Bartter-Like Syndrome

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12 December 2020

based on heuristic

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Extracellular calcium‐sensing receptor dysfunction is associated with two new phenotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25506941

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25506941

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0115178

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2014PLoSO...9k5178L

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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