The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1 (Q38334131)

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scientific article published on August 1, 1991

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English	The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1	scientific article published on August 1, 1991

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scholarly article

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Europe PubMed Central

PMC publication ID

2 September 2017

The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1 (English)

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Europe PubMed Central

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2 September 2017

0 references

immunosuppression

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based on heuristic

inferred from title

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10.1128/MCB.11.8.4074-4087.1991

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5 November 2022

author name string

S. S. Banerji

1

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J. N. Parsons

2

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M. J. Tocci

3

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publication date

1 August 1991

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http://mcb.asm.org/cgi/content/abstract/11/8/4074

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5 November 2022

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Portable Document Format

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5 November 2022

https://journals.asm.org/doi/pdf/10.1128/mcb.11.8.4074-4087.1991

1 reference

10.1128/MCB.11.8.4074-4087.1991

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Molecular and Cellular Biology

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2 September 2017

11

1 reference

Europe PubMed Central

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2 September 2017

8

1 reference

Europe PubMed Central

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2 September 2017

4074-4087

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

1 reference

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6 September 2017

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription

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Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

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Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products

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6 September 2017

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells

1 reference

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6 September 2017

Identification of a putative regulator of early T cell activation genes

1 reference

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6 September 2017

Characterization of antigen receptor response elements within the interleukin-2 enhancer

1 reference

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6 September 2017

The NF-kappa B-binding site mediates phorbol ester-inducible transcription in nonlymphoid cells

1 reference

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6 September 2017

I kappa B: a specific inhibitor of the NF-kappa B transcription factor

1 reference

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6 September 2017

T-cell-specific expression of interleukin 2: evidence for a negative regulatory site

1 reference

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6 September 2017

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor

1 reference

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6 September 2017

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=361217

6 September 2017

Sequential expression of genes involved in human T lymphocyte growth and differentiation

1 reference

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6 September 2017

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins

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6 September 2017

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

1 reference

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6 September 2017

Contingent genetic regulatory events in T lymphocyte activation

1 reference

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6 September 2017

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1 reference

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6 September 2017

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=361217

6 September 2017

Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=361217

6 September 2017

NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation

1 reference

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The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein

1 reference

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6 September 2017

Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene

1 reference

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6 September 2017

The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements

1 reference

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6 September 2017

Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=361217

6 September 2017

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1 reference

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6 September 2017

FK 506 for liver, kidney, and pancreas transplantation

1 reference

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6 September 2017

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

1 reference

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6 September 2017

Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction.

1 reference

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6 September 2017

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

1 reference

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Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A

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Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression

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NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells

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The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.

1 reference

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1 reference

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1 reference

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Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

1 reference

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1 reference

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter

1 reference

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The Use of Cyclosporin A Immunosuppression in Organ Grafting

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1 reference

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1 reference

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1 reference

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1 reference

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Variation in enzymatic transient gene expression assays

1 reference

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Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

1 reference

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Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5'-flanking sequences.

1 reference

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23 June 2018

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1 reference

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23 June 2018

Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes.

1 reference

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23 June 2018

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin

1 reference

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31 August 2018

Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Two regions within the human IL-2 gene promoter are important for inducible IL-2 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A inhibits late steps of T lymphocyte activation after transmembrane signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cyclosporine A on T lymphocytes and accessory cells from human blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunosuppressive effects of cyclosporin A on cloned T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A-mediated inhibition of mitogen-induced gene transcription is specific for the mitogenic stimulus and cell type

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of interleukin-2 receptor-alpha gene expression is regulated by post-translational activation of kappa B specific DNA binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunosuppressive effect of FK506 on collagen-induced arthritis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.11.8.4074

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

10.1128/MCB.11.8.4074-4087.1991

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1712901

5 November 2022

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Sitelinks

Wikipedia(0 entries)

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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