NMR-based functional profiling of RASopathies and oncogenic RAS mutations. (Q36712670)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23487764%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

NMR-based functional profiling of RASopathies and oncogenic RAS mutations (English)

1 reference

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25 February 2020

1

1 reference

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25 February 2020

Mitsuhiko Ikura

series ordinal

3

1 reference

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25 February 2020

author name string

Benjamin G Neel

series ordinal

2

1 reference

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25 February 2020

language of work or name

English

0 references

publication date

4 March 2013

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

25 February 2020

published in

1 reference

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25 February 2020

volume

110

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25 February 2020

issue

12

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25 February 2020

page(s)

4574-4579

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Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

25 February 2020

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SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations

30 September 2017

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What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf

30 September 2017

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Allosteric gating of Son of sevenless activity by the histone domain

30 September 2017

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Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

30 September 2017

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The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

30 September 2017

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Regulation of the Ras-GTPase activating protein neurofibromin by C-tail phosphorylation: implications for protein kinase C/Ras/extracellular signal-regulated kinase 1/2 pathway signaling and neuronal differentiation

30 September 2017

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Membrane-dependent signal integration by the Ras activator Son of sevenless

30 September 2017

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Germline gain-of-function mutations in SOS1 cause Noonan syndrome

30 September 2017

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A Ras-induced conformational switch in the Ras activator Son of sevenless

30 September 2017

1 reference

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Structural analysis of autoinhibition in the Ras activator Son of sevenless

30 September 2017

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Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

30 September 2017

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

30 September 2017

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Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

30 September 2017

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Targeting RAS signalling pathways in cancer therapy

30 September 2017

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Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells

30 September 2017

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The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

30 September 2017

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Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras

30 September 2017

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Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP.

30 September 2017

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Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

30 September 2017

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Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules

30 September 2017

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Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity

30 September 2017

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Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

30 September 2017

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Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

30 September 2017

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K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.

30 September 2017

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Comparative biochemical properties of normal and activated human ras p21 protein

28 June 2018

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Biological and biochemical properties of human rasH genes mutated at codon 61.

28 June 2018

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Differential regulation of rasGAP and neurofibromatosis gene product activities

28 June 2018

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28 June 2018

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Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

5 September 2018

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Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

5 September 2018

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Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

5 September 2018

1 reference

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Neurofibromatosis type 1 gene mutations in neuroblastoma

5 September 2018

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Yeast and mammalian ras proteins have conserved biochemical properties

5 September 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1218173110

Hurdles and complexities of codon 13 KRAS mutations

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23487764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23487764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23487764

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1218173110

1 reference

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25 February 2020

0 references

1 reference

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25 February 2020

PubMed publication ID

23487764

1 reference

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