Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. (Q53341825)

13 May 2018

http://europepmc.org/abstract/MED/10878813

title

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. (English)

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10878813

author name string

Herreman A

1

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13 May 2018

http://europepmc.org/abstract/MED/10878813

Serneels L

2

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13 May 2018

http://europepmc.org/abstract/MED/10878813

Annaert W

3

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10878813

Collen D

4

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10878813

Schoonjans L

5

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10878813

De Strooper B

6

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10878813

publication date

1 July 2000

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13 May 2018

http://europepmc.org/abstract/MED/10878813

published in

Nature Cell Biology

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13 May 2018

http://europepmc.org/abstract/MED/10878813

volume

2

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13 May 2018

http://europepmc.org/abstract/MED/10878813

issue

7

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13 May 2018

http://europepmc.org/abstract/MED/10878813

page(s)

461-462

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13 May 2018

http://europepmc.org/abstract/MED/10878813

cites work

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

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7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Signalling downstream of activated mammalian Notch

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7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

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7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

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7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

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7 January 2021

Identifiers

DOI

10.1038/35017105

1 reference

13 May 2018

http://europepmc.org/abstract/MED/10878813

1 reference

13 May 2018