Nuclear factor kappa B subunit 1 (Q4044834)

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mammalian protein found in Homo sapiens
  • nuclear factor NF-kappa-B p105 subunit
  • NF-kappabeta
  • nuclear factor kappa-B DNA binding subunit
  • EBP-1
  • NFKB1
  • nuclear factor NF-kappa-B p50 subunit
  • DNA-binding factor KBF1
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
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Language Label Description Also known as
English
Nuclear factor kappa B subunit 1
mammalian protein found in Homo sapiens
  • nuclear factor NF-kappa-B p105 subunit
  • NF-kappabeta
  • nuclear factor kappa-B DNA binding subunit
  • EBP-1
  • NFKB1
  • nuclear factor NF-kappa-B p50 subunit
  • DNA-binding factor KBF1
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Statements

part of
molecular function
protein binding
determination method or standard
IPI
32 references
retrieved
8 April 2019
stated in
Identification of a novel protein from glial cells based on its ability to interact with NF‐κB subunitsr
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3)
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-α-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Notch1 augments NF-kappaB activity by facilitating its nuclear retention
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a novel protein from glial cells based on its ability to interact with NF‐κB subunitsr
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of an IkappaBalpha/NF-kappaB complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
The RNA aptamer disrupts protein-protein interaction between beta-catenin and nuclear factor-kappaB p50 and regulates the expression of C-reactive protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
COMMD proteins, a novel family of structural and functional homologs of MURR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
retrieved
8 April 2019
stated in
Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+-dependent manner
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IEA
retrieved
8 April 2019
stated in
α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IDA
retrieved
8 April 2019
stated in
Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus
GOA
curator
UniProt
UniProt protein ID
P19838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IDA
retrieved
8 April 2019
stated in
Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19838
determination method or standard
IDA
biological process

Identifiers

MeSH descriptor ID
D052002
subject named as
NF-kappa B p50 Subunit
0 references
 
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