The human Mi-2/NuRD complex and gene regulation (Q28240457)

https://api.crossref.org/works/10.1038/SJ.ONC.1210611

Europe PubMed Central

title

The human Mi-2/NuRD complex and gene regulation (English)

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author name string

S A Denslow

series ordinal

1

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P A Wade

series ordinal

2

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language of work or name

English

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publication date

13 August 2007

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published in

Oncogene

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volume

26

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issue

37

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page(s)

5433-8

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1 reference

p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction

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Histone deacetylase activity is required for full transcriptional repression by mSin3A

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The NuRD component Mbd3 is required for pluripotency of embryonic stem cells

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The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2

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Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

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Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

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The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development

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