Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions (Q24532168)

MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase

Europe PubMed Central

title

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions (English)

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W Kolch

1

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language of work or name

English

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publication date

15 October 2000

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published in

Biochemical Journal

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volume

351 Pt 2

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page(s)

289-305

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cites work

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The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf

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Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

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14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation

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A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

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Functional analysis of CNK in RAS signaling

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The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases

24 March 2017

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

24 March 2017

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

24 March 2017

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KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation

24 March 2017

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Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells

24 March 2017

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

24 March 2017

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

24 March 2017

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Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation

24 March 2017

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CNK, a RAF-binding multidomain protein required for RAS signaling

24 March 2017

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The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation

24 March 2017

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MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

24 March 2017

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Autoregulation of the Raf-1 serine/threonine kinase

24 March 2017

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GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1

24 March 2017

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BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

24 March 2017

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Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

24 March 2017

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Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

24 March 2017

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Bcl-2 targets the protein kinase Raf-1 to mitochondria

24 March 2017

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Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

24 March 2017

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Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase

24 March 2017

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

24 March 2017

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Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

24 March 2017

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RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

24 March 2017

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Activation of Raf-1 by 14-3-3 proteins

24 March 2017

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Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins

24 March 2017

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

24 March 2017

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14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

24 March 2017

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Crystal structure of the zeta isoform of the 14-3-3 protein

24 March 2017

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Cdc37 is a molecular chaperone with specific functions in signal transduction

24 March 2017

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

24 March 2017

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The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

24 March 2017

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Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

24 March 2017

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

24 March 2017

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Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

24 March 2017

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Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

24 March 2017

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Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

24 March 2017

1 reference

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The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1

24 March 2017

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

24 March 2017

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

24 March 2017

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TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

24 March 2017

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Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

24 March 2017

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Signaling by dual specificity kinases

24 March 2017

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p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

24 March 2017

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

24 March 2017

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Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases

24 March 2017

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Murine Ksr interacts with MEK and inhibits Ras-induced transformation

24 March 2017

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14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

24 March 2017

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Kinase suppressor of Ras is ceramide-activated protein kinase

24 March 2017

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The complexity of Raf-1 regulation

24 March 2017

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

24 March 2017

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14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules

24 March 2017

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Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

24 March 2017

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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

24 March 2017

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Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo

24 March 2017

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A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase

24 March 2017

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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

24 March 2017

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Two distinct Raf domains mediate interaction with Ras

24 March 2017

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From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site

24 March 2017

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Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner

24 March 2017

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Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

24 March 2017

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Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

24 March 2017

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Raf-1 activates MAP kinase-kinase

24 March 2017

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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

24 March 2017

1 reference

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Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

24 March 2017

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Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt

24 March 2017

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Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

24 March 2017

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

24 March 2017

1 reference

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Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1

24 March 2017

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cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

24 March 2017

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

24 March 2017

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KSR modulates signal propagation within the MAPK cascade

24 March 2017

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The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner

24 March 2017

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Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1

24 March 2017

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14-3-3 proteins: structure, function, and regulation

24 March 2017

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

7 April 2017

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Mitogen-activated protein kinase pathways

7 April 2017

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

7 April 2017

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Formation of the Ras dimer is essential for Raf-1 activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

14-3-3 proteins block apoptosis and differentially regulate MAPK cascades

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Isotype-specific functions of Raf kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

14-3-3 proteins: eukaryotic regulatory proteins with many functions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

CK2: a protein kinase in need of control.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Paradoxical activation of Raf by a novel Raf inhibitor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

27 September 2017

Chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Synergistic activation of mitogen-activated protein kinase by cyclic AMP and myeloid growth factors opposes cyclic AMP's growth-inhibitory effects.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

KSR stimulates Raf-1 activity in a kinase-independent manner

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The regulatory subunit of protein kinase CK2 is a specific A-Raf activator

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

A-Raf kinase is a new interacting partner of protein kinase CK2 beta subunit

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

TC21 causes transformation by Raf-independent signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Negative regulation of Raf-1 by phosphorylation of serine 621.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

KSR: a novel player in the RAS pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The 3Rs of life: Ras, Raf and growth regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Raf meets Ras: completing the framework of a signal transduction pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

14-3-3: modulators of signaling proteins?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Bcr and Raf form a complex in vivo via 14-3-3 proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Characterization of IkappaB kinases. IkappaB-alpha is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Phosphorylation of Raf by ceramide-activated protein kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The Raf/MAP kinase cascade in cell cycle regulation and differentiation in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

JNK is involved in signal integration during costimulation of T lymphocytes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The post-translational modification of ras p21 is important for Raf-1 activation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Signal transduction through MAP kinase cascades

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The immunophilin FKBP65 forms an association with the serine/threonine kinase c-Raf-1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Increasing complexity of Ras signal transduction: involvement of Rho family proteins

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

The protein kinase KSR interacts with 14-3-3 protein and Raf.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Identification of the major phosphorylation sites of the Raf-1 kinase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Mechanism of inhibition of Raf-1 by protein kinase A.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Raf-1 kinase and ERK2 uncoupled from mitogenic signals in rat fibroblasts.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Dual function of Ras in Raf activation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Physical association with ras enhances activation of membrane-bound raf (RafCAAX).

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

29 November 2018

1 reference

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Signal transduction. How receptors turn Ras on.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221363

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

Identification of the 14.3.3 zeta domains important for self-association and Raf binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

The Raf-1 serine-threonine kinase is a substrate for the p56lck protein tyrosine kinase in human T-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

Different effects of various phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020

Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11023813

12 December 2020