AXL receptor tyrosine kinase (Q21991362)

http://www.ebi.ac.uk/interpro/protein/Q00993

Immunoglobulin-like fold

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

Protein kinase-like domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

Immunoglobulin-like domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

membrane protein

1 reference

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Protein kinase domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

protein heterodimerization activity

IPI

1 reference

14 February 2019

Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

transmembrane receptor protein tyrosine kinase activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

1 reference

24 April 2018

protein tyrosine kinase activity

transmembrane signaling receptor activity

3 references

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

Wnt-protein binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

intracellular anatomical structure

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

cytoplasm

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

integral component of plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

receptor complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

cellular response to extracellular stimulus

biological process

IDA

1 reference

14 February 2019

Screen for genes regulated during early kidney morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

negative regulation of neuron apoptotic process

IDA

Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

dendritic cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

protein kinase B signaling

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

secretion by cell

1 reference

14 February 2019

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

vagina development

1 reference

14 February 2019

High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

negative regulation of lymphocyte activation

1 reference

14 February 2019

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

neuron migration

AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

cell maturation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

platelet activation

1 reference

7 November 2018

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

blood vessel remodeling

1 reference

14 February 2019

Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

forebrain cell migration

1 reference

14 February 2019

Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

phagocytosis

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

24 April 2018

Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

ovulation cycle

1 reference

14 February 2019

Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

negative regulation of tumor necrosis factor production

1 reference

14 February 2019

Twist mediates suppression of inflammation by type I IFNs and Axl

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

substrate adhesion-dependent cell spreading

1 reference

14 February 2019

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

1 reference

14 February 2019

inflammatory response

1 reference

14 February 2019

Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

enzyme linked receptor protein signaling pathway

1 reference

14 February 2019

Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

natural killer cell differentiation

1 reference

7 November 2018

Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

apoptotic cell clearance

Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

positive regulation of protein kinase B signaling

1 reference

7 November 2018

Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

animal organ regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

negative regulation of cytokine production

1 reference

14 February 2019

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

neutrophil clearance

1 reference

14 February 2019

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

cell differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

negative regulation of apoptotic process

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

24 April 2018

Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

24 April 2018

Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

24 April 2018

Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

phagocytosis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

negative regulation of signal transduction

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

Wnt signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

cell differentiation

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

7 November 2018

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

negative regulation of apoptotic process

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

positive regulation of ERK1 and ERK2 cascade

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00993&geneProductId=UniProtKB:Q00993

natural killer cell differentiation

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

nervous system development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

cell migration

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00993

platelet activation

positive regulation of protein kinase B signaling

2 references

has part(s)

immunoglobulin subtype

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

fibronectin type III

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

tyrosine-protein kinase, catalytic domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

tyrosine-protein kinase, active site

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

immunoglobulin-like domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

protein kinase, ATP binding site

1 reference

http://www.ebi.ac.uk/interpro/protein/Q00993

protein kinase domain

1 reference