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Imaging in Drug Discovery and Early Clinical TrialsVerlagsort, Verlag, Jahr: Basel, Birkhäuser Verlag, 2005 Umfang: Online-Ressource (X, 392 p, digital) Schlagwort: Arzneimittelentwicklung , Bildgebendes Verfahren Schlagwort: Arzneimittelprüfung , Bildgebendes Verfahren Schlagwort: Bildgebendes Verfahren , Arzneimittelforschung , Klinisches Experiment Schlagwort: Bildverarbeitung , Arzneimittelentwicklung , Klinisches Experiment ISBN: 978-3-7643-7426-6 in die Merkliste |
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Titel: Imaging in Drug Discovery and Early Clinical Trials
Hrsg./Bearb.:
Hrsg./Bearb.:
Hrsg./Bearb.:
Medientyp: lokal emedia ebook
Verf.Vorl.: edited by Paul L. Herrling, Alex Matter, Markus Rudin
Abrufzeichen Regio: cofz
Verlagsort: Basel
Verlag: Birkhäuser Verlag
ISBN: 978-3-7643-7426-6
Jahr: 2005
Jahr: 2005
Umfang: Online-Ressource (X, 392 p, digital)
Serie/Reihe: Progress in Drug Research ; 62
Serie/Reihe: SpringerLink : Bücher
K10plus_PPN: 1647326400
Fußnoten: Includes bibliographical references and index
Sprache: eng
Inhalt: The drug discovery process -- Imaging modalities: principles and information content -- Magnetic resonance and fluorescence based molecular imaging technologies -- Studying molecular and cellular processes in the intact organism -- Disease phenotyping: structural and functional readouts -- Evaluation of drug candidates: Efficacy readouts during lead optimization -- Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities -- Pharmacokinetic studies with PET -- Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development -- Clinical drug evaluation using imaging readouts: regulatory perspectives
Inhalt: The impact of genomics on biomedical research and the development of efficient technology platforms allowing for highly parallel compound synthesis and screening procedures have led to a major paradigm shift in drug discovery and development. Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation. A chapter describes imaging biomarkers, their development, advantages and the potential pitfalls associated with their use. In the translation of imaging tools from animals to man regulatory issues have to be addressed, which are dealt with in a separate section. The monograph provides a comprehensive overview on the role of imaging in drug discovery today and discusses major developments and trends both with regard to technologies and applications
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Schlagwort:
Schlagwort: Bildgebendes Verfahren / Arzneimittelforschung / Klinisches Experiment
Schlagwort: Bildverarbeitung / Arzneimittelentwicklung / Klinisches Experiment
URL-Hinweis: Resolving-System
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URL-Hinweis: Inhaltstext
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URL: 10.1007/3-7643-7426-8
Medienart: Online-Ressource
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