Angular.JS and Node.JS are both JavaScript technologies, but they differ in their functionality and usage. Angular.JS is a front-end framework for building client-side web applications, while Node.JS is a back-end runtime environment used for building server-side and networking applications. Some key differences are that Angular.JS provides features like data binding and dependency injection for dynamic web apps, while Node.JS enables writing database queries and building scalable apps with asynchronous APIs. Developers should choose between them based on whether they need a front-end or back-end framework to suit their specific project requirements.