Dermatomyosi

tis
Disease
Teacher : Nada Ayoub

Biology project
2024/2025
information form group;

Mousa ,Soliman ,Salsabila ,

larine, sondos
 Table of Roles
Cause of
01 dermatomyositis
Here we going to be talking
about how dermatologists
caused of.
Information from Larein
mais
 Table of Roles
Cause of
01 dermatomyositis
Here we going to be talking
about how dermatologists
caused of.
Information from Larein
mais

Here we going to talk

Treatment
about how this disease
02 was cured
information from
Salsabel
 Table of Roles
Cause of
01 dermatomyositis
Here we going to be talking
about how dermatologists
caused of.
Information from Larein
mais

Here we going to talk

Treatment
about how this disease
02 was cured
information from
Salsabel

Symptoms
03 Here we going to talk
about signs of
dermatomyositis
information from
 Table of Roles
Cause of
01 dermatomyositis
Here we going to be talking
about how dermatologists
caused of.
Information from Larein
mais
Here we going to talk
History
Here we going to talk
Treatment
about how this disease
04 when was
dermatomyositis

02 was cured
information from
discovered .
Information from
Soliman
Salsabel

Symptoms
03 Here we going to talk
about signs of
dermatomyositis
information from
 Table of Roles
Cause of
01 dermatomyositis
Here we going to be talking
about how dermatologists
caused of.
Information from Larein
mais
Here we going to talk
History
Here we going to talk
Treatment
about how this disease
04 when was
dermatomyositis

02 was cured
information from
discovered .
Information from
Soliman
Salsabel

Symptoms 05 Frequency/rate
Here we goin to talk

03 Here we going to talk

about signs of
about the rates of and
freaquency of
dermatomyosists
dermatomyositis By mousa
information from
0 Causes

1
The cause of
dermatomyositis (DM) is
unknown, Experts think it
may be due to a viral
infection of the muscles ar a
problem with the body's
immune system. It may also
occur in people who have
cancer in the abdomen,
lung, or other parts of the
body Anyone can develop
this conditionat it most
aften affects adults ages
2 Treatment
The two most common medications for dematomyo sities
are azathioprine (Azanı Imuran) and methotrexate
(Trexall). -Mycophenolate mofetil (Cellcept) is another
medication used to treat dermatomyosities, particulary if
the lungs are involved. Rituximab (Rituxan). The high
doseoral corticosteroids, followed by the addition of
immunoglobulin in refractory cases.
3Symptoms of the Disease
Dermatomyositis is a long term
inflammatory which affects the
skin and the muscles its
symptoms are generally a skin
rash and worsening muscle
weakness overtime. These
may occur suddenly or develop
over the months other
symptoms may include weight
loss , fever, lung inflammation,
or light sensitivity.
4.1 History
The first detailed descriptions of patients with rare
muscle disease (acute form of myositis) with
cutaneous lesions were reported by E. Wagner [1] in
1863 and P. Potain (1875) [2]. These authors
introduced to the medical community a new group of
IIMs, characterized by the damage of many skeletal
muscles and by skin manifestations. These
disorders are rare, but increasingly recognized. They
have avariety of clinical manifestations,
immunological abnormalities and courses, and form
a diverse group of diseases with unclear causes.
The most common forms of these disorders are
dermatomyositis (DM) and polymyositis (PM) [3].
4.2 History
In 1887, Professor Hans Unvericht published a description of a peculiar
muscle disease with fatigue and malaise, muscle pain and weakness,
swelling of face, and bluish lesions over eyelids [4]. He reported a 27-year-
old stonemason, who developed acute onset of weakness, stiffness, and
pain in the proximal arm, leg, and back muscles. A week later, diffuse
swelling of face and extremities, accompanied by a low-grade evening
fevers and a bluish rash over his eyelids, had developed. Over the next few
days the patient noticed shortness of breath, thickening of the voice, and
dysphagia. After several weeks, the patient died with cyanosis and clinical
manifestation of a pulmonary arrest. Autopsy showed fluid- filled lungs and
swollen proximal muscles. Histopathological examination showed various
stages of degeneration of muscle fibers, and focal round-cell interstitial
infiltration of the affected muscles. In 1891, Unvericht reported a second
case and gave a name to this disorder
4.3 History
developed acute onset of weakness, stiffness, and
pain in the proximal arm, leg, and back muscles. A
week later, diffuse swelling of face and extremities,
accompanied by a low-grade evening fevers and a
bluish rash over his eyelids, had developed. Over the
next few days the patient noticed shortness of breath,
thickening of the voice, and dysphagia. After several
weeks, the patient died with cyanosis and clinical
manifestation of a pulmonary arrest. Autopsy showed
fluid- filled lungs and swollen proximal muscles.
Histopathological examination showed various stages
of degeneration of muscle fibers, and focal round-cell
interstitial infiltration of the affected muscles. In 1891,
Unvericht reported a second case and gave a name to
this disorder dermatomyositis [5].
5 Frequency/rate
Timeline As the years pass and population gets
more the more people get infected

1863 1987 The number of

people getting
Around 79 to 108 infected increased
from an average
per year people 1095 people per
got infected year to 10864

1887 2025
In 1887 the number of In 2025 people
people getting
infected started
get infected on
increasing form an an average per
average of 108 per year 100k people
year to 799
Prevalence

Germany
10% to 12%

Japan 17%

Usa 30%to
40%