Depressive Disoder
Depressive Disoder
disorders
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Introduction
Mood can be defined as a pervasive and
sustained emotion or feeling tone that
influences a person’s behavior and colors his
or her perception of being in the world.
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Etiology
Biological factors
Biogenic amines
Genetic Factors
Family studies:
▪ One parent, 10 -25 and if both 2x
▪ Twins studies, MZ: 70-90 and DZ: 16-35
Psychosocial factors
▪ Unemployment
▪ Loss spouse
▪ Loss of family
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General truth
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Perceptual Disturbances
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Classification
1. Disruptive mood dysregulation disorder
2. Major depressive disorder
3. Persistent depressive disorder
4. Premenstrual dysphoric disorder
5. Substance/medication-induced
depressive disorder
6. Depressive disorder due to another
medical condition
7. Other specified depressive disorder, and
8. Unspecified depressive disorder.
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Depressive disorders,
cont’d…
The common feature of all of these disorders
is the presence of
Sad
Empty
Irritable mood
Accompanied by related changes that
significantly affect the individual’s capacity to
function (e.g., somatic and cognitive
changes in major depressive disorder and
persistent depressive disorder).
What differs among them are issues of
duration, timing, or presumed etiology 7
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1. Disruptive Mood
Dysregulation Disorder
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1. Disruptive Mood
Dysregulation Disorder, con’d..
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1. Disruptive Mood
Dysregulation Disorder, con’d..
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2. Major Depressive
Disorder
17 % - Life time prevalence MDD
F:M = 2:1
20 – 50 age common
Common for divorced/separated
Common for rural areas than urban
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2. Major Depressive
Disorder, cont’d…
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2. Major Depressive
Disorder, cont’d…
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2. Major Depressive
Disorder, cont’d…
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2. Major Depressive
Disorder, cont’d…
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2. Major Depressive
Disorder, cont’d…
Development and Course
May first appear at any age
But the likelihood of onset increases
markedly with puberty
Incidence appears to peak in the 20s
The course of depression may reflect
social-structural adversity associated with
poverty, racism, and marginalization.
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2. Major Depressive
Disorder, cont’d…
Risk and Prognostic Factors
Temperamental --- Negative affectivity
Environmental --- life events, sex, socio-
economic, work types….
Genetic and physiological----First-degree
family members
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2. Major Depressive
Disorder, cont’d…
Differential Diagnosis
Manic episodes with irritable mood or with
mixed features
Bipolar I disorder, bipolar II disorder, or other
specified bipolar and related disorder
Depressive disorder due to another medical
condition
Substance/medication-induced depressive
disorder
Persistent depressive disorder
Schizoaffective disorder
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2. Major Depressive
Disorder, cont’d…
Treatment
Antidepressants
▪ TCAs
▪ SSRAIs
Antipsychotic --- when needed (with
psychotic feature)
Psychotherapy
▪ CBT,….
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3. Persistent Depressive
Disorder
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3. Persistent Depressive
Disorder, cont’d…
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4. Premenstrual Dysphoric
Disorder
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4. Premenstrual Dysphoric
Disorder, cont’d…
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4. Premenstrual Dysphoric
Disorder, cont’d…
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5. Substance/Medication-
Induced Depressive Disorder
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5. Substance/Medication-
Induced Depressive Disorder,
cont’d..
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6. Depressive Disorder Due
to Another Medical Condition
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7. Other Specified
Depressive Disorder
Clinically significant distress or impairment
in social, occupational, or other important
areas of functioning predominate
But do not meet the full criteria for any of
the disorders in the depressive disorders
The clinician chooses to communicate
the specific reason that the presentation
does not meet the criteria for any specific
depressive disorder
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7. Other Specified
Depressive Disorder, cont’d…
Examples:
Recurrent brief depression
Depressive episode with insufficient
symptoms
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8. Unspecified Depressive
Disorder
Cause clinically significant distress or
impairment in social,
occupational, or other important areas of
functioning predominate
But do not meet the full criteria for any
of the disorders in the depressive
disorders
The clinician chooses not to specify
the reason that the criteria are not met
for a specific depressive disorder
e.g., in emergency room settings
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Individual Assignment
(Submit before exam)
1. Ethiology of depressive disorders
2. Prevalence of each depressive
disorders
3. Differential diagnosis of depressive
disorders
4. Specifiers
5. Treatment of each depressive
disorders
6. Changes from DSM-IV to DSM-5
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Thanks!
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