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Metallo Protein

Metalloproteins are proteins that contain metal ion cofactors essential for their biological functions, categorized into enzymes, transport proteins, storage proteins, and regulatory proteins. Common metal ions include iron, which plays a crucial role in various cellular processes, with examples like hemoglobin for oxygen transport and myoglobin for oxygen storage. Metalloproteins also have applications in medicine as antibacterial and anticancer agents, as well as in environmental science for water purification and soil remediation.

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Neha Jamdhade
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83 views11 pages

Metallo Protein

Metalloproteins are proteins that contain metal ion cofactors essential for their biological functions, categorized into enzymes, transport proteins, storage proteins, and regulatory proteins. Common metal ions include iron, which plays a crucial role in various cellular processes, with examples like hemoglobin for oxygen transport and myoglobin for oxygen storage. Metalloproteins also have applications in medicine as antibacterial and anticancer agents, as well as in environmental science for water purification and soil remediation.

Uploaded by

Neha Jamdhade
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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Metalloprotein

Name = Borse Madhuri Dipak


Class = M.Sc 1 (Analytical
Chemistry)
Topic = Metalloprotein
What is metalloprotein:
• Metalloproteins are proteins that contains a metal ion cofactor, which
is essential for their biological function.
• These metal ions can be either tightly bound to the protein.
Types of
Metalloprotein
1. Enzymes: Metalloenzymes use metal ions to catalyze chemical
reaction.
2. Transport proteins: Metalloproteins transport metal ions or other
molecules.
3. Storage proteins: Metalloprotein storage metal ion.
4. Regulatory proteins:Metalloproteins regulate genes expression to DNA
and RNA.
Common Metal ions
• Iron: Iron is a chemical element with the symbol Fe and atomic
number 26 it is a silvery-white and soft metal.In biological systems
iron plays a crucial role in various cellular processes including.
Example of proteins and their
functions
1. Hemoglobin
• Hemoglobin are metalloprotein.
• Found in red blood cells(RBCs).
• Red colour of blood is because of hemoglobin(HB).
• O2 transfer from hemoglobin.
2. Myoglobin:
• Myglobin present in muscles.
• Oxygen storage for mypoglobin.
• Simple structure of myoglobin compare to hemoglobin.
• 153 amino acid are present in myoglobin.
3. Cytochromes
• Cytochromes are redox-active proteins.
• Central Fe atom present in cytochromes.
• These are electrons transferred.
• These are four types:-
Cytochrome a – heme A
Cytochrome b – heme B
Cytochrome c – heme C
Cytochrome d – heme d
4. Rubredoxin
• Low molecular weight.
• A bacterial protein.
• It involve in electron transfer.
• It has regular tetrahedral structure.
Medicine:

• Antibacterial agents: Metalloproteins like lactoferrin have antibacterial


properties.
• Anticancer agents: Metalloproteins like cisplatin are used in cancer
treatment.
Environmental Science
1. Water Purification: Metalloprotein can be used to remove heavy
metals and other pollutants from water.
2. Soil remediation: Metalloprotein can be used to clean a
contaminated soil.

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