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CELL
ORGANELLES AND THEIR FUNCTIONS Dr. Sabahat Ali CYTOPLASM AND ITS ORGANELLES
The cytoplasm is fi lled with both minute
and large dispersed particles and organelles. The clear fl uid portion of the cytoplasm in which the particles are dispersed is called cytosol; this contains mainly dissolved proteins, electrolytes, and glucose. Dispersed in the cytoplasm are neutral fat globules, glycogen granules, ribosomes, secretory vesicles, and fi ve especially important organelles: the endoplasmic reticulum, the Golgi apparatus, mitochondria, lysosomes, and peroxisomes. Dr. Sabahat Ali ENDOPLASMIC RETICULUM
A network of tubular and fl at vesicular
structures in the cytoplasm; this is the endoplasmic reticulum. The tubules and vesicles interconnect with one another. Also, their walls are constructed of lipid bilayer membranes that contain large amounts of proteins, similar to the cell membrane. The total surface area of this structure in some cells—the liver cells, for instance—can be as much as 30 to 40 times the cell membrane area. The space inside the tubules and vesicles is fi lled with endoplasmic matrix, a watery medium that is diff erent from the fl uid in the cytosol outside the endoplasmic reticulum. Dr. Sabahat Ali RIBOSOMES AND THE GRANULAR ENDOPLASMIC RETICULUM Attached to the outer surfaces of many parts of the endoplasmic reticulum are large numbers of minute granular particles called ribosomes. Where these are present, the reticulum is called the granular endoplasmic reticulum or rough endoplasmic reticulum (RER). The ribosomes are composed of a mixture of RNA and proteins, and they function to synthesize new protein molecules in the cell. Dr. Sabahat Ali A SMOOTH ENDOPLASMIC RETICULUM
Part of the endoplasmic
reticulum has no attached ribosomes. This part is called the smooth, endoplasmic reticulum. The SER functions for the synthesis of lipid substances and for other processes of the cells promoted by intrareticular enzymes.
Dr. Sabahat Ali
GOLGI APPARATUS
The Golgi apparatus, is closely
related to the endoplasmic reticulum. It has membranes similar to those of the a granular endoplasmic reticulum. It is usually composed of four or more stacked layers of thin, fl at, enclosed vesicles lying near one side of the nucleus.
Dr. Sabahat Ali
THE GOLGI APPARATUS FUNCTION
The Golgi apparatus functions in
association with the endoplasmic reticulum. small "transport vesicles” (also called endoplasmic reticulum vesicles, or ER vesicles) continually pinch off from the endoplasmic reticulum and shortly thereafter fuse with the Golgi apparatus. In this way, substances entrapped in the ER vesicles are transported from the endoplasmic reticulum to the Golgi apparatus. The transported substances are then processed in the Golgi apparatus to form lysosomes, secretory vesicles, and other cytoplasmic components. Dr. Sabahat Ali LYSOSOMES
Lysosomes, are vesicular organelles
that form by breaking off from the Golgi apparatus and then dispersing throughout the cytoplasm. The lysosomes provide an intracellular digestive system that allows the cell to digest (1) damaged cellular structures, (2) food particles that have been ingested by the cell, (3) unwanted matter such as bacteria. Dr. Sabahat Ali MITOCHONDRIA
The mitochondria, are called the “powerhouses” of the cell.
Without them, cells would be unable to extract enough energy from the nutrients, and essentially all cellular functions would cease. Mitochondria are present in all areas of each cell’s cytoplasm, but the total number per cell varies from less than a hundred up to several thousand, depending on the amount of energy required by the cell. Further, the mitochondria are concentrated in those portions of the cell that are responsible for the major share of its energy metabolism. Dr. Sabahat Ali The basic structure of the mitochondrion, is composed mainly of two lipid bilayer–protein membranes: an outer membrane and an inner membrane. Many in folding of the inner membrane form shelves onto which oxidative enzymes are attached. In addition, the inner cavity of the mitochondrion is fi lled with a matrix that contains large quantities of dissolved enzymes that are necessary for extracting energy from nutrients. Dr. Sabahat Ali These enzymes operate in association with the oxidative enzymes on the shelves to cause oxidation of the nutrients, thereby forming carbon dioxide and water and at the same time releasing energy. The liberated energy is used to synthesize a “high-energy” substance called adenosine triphosphate (ATP). ATP is then transported out of the mitochondrion, and it diff uses throughout the cell to release its own energy wherever it is needed for performing cellular functions. Mitochondria are self-replicative, which means that one mitochondrion can form a second one, a third one, and so on, whenever there is a need in the cell for increased amounts of ATP. Indeed, the mitochondria contain DNA similar to that found in the cell nucleus. Dr. Sabahat Ali NUCLEUS
The nucleus is the control center of the cell. Briefl y,
the nucleus contains large quantities of DNA, which are the genes. The genes determine the characteristics of the cell’s proteins, including the structural proteins, as well as the intracellular enzymes that control cytoplasmic and nuclear activities. The genes also control and promote reproduction of the cell itself. The genes fi rst reproduce to give two identical sets of genes; then the cell splits by a special process called Dr. Sabahat Ali Dr. Sabahat Ali CELL DIVISION
Cell division is the process by which a parent cell divides into
two daughter cells. Cell division usually occurs as part of a larger cell cycle in which the cell grows and replicates its chromosome(s) before dividing. The three main functions of cell division are reproduction, growth and gamete formation. Mitosis is required for asexual reproduction, growth, repair and regeneration. It is a reduction division is a special type of cell division of germ cells in sexually-reproducing organisms that produces the gametes, such as sperm or egg cells. Dr. Sabahat Ali CELL DIVISION