Nervous System 2023
Nervous System 2023
Definition:
The system which is responsible to adjust the body in response to either
external or internal environmental changes is known as nervous system.
NERVOUS SYSTEM
Multipolar
Neurons
1.An axon lying near a Schwann cell invaginates into the cytoplasm of the Schwann cell.
2.The plasma membrane of a Schwann cell extends and becomes greatly elongated and comes to be spirally
wound around the axon, which is thus surrounded by many layers of plasma membrane.
3.These layers form myelin sheath consisting of alternating concentric layers of lipid and protein materials.
4.Outside the myelin sheath, an additional sheath, called the neurilemma is formed.
5.In fact the neurilemma is Schwann cell cytoplasm which is also called Schwann cell sheath. Schwann cell
nucleus is also present in a segment of myelin sheath.
1. Apolar neuron == Without any process. Location Cutaneous neuron
These are supporting cells which form a packing around the neurons in
the brain and spinal cord.
Function:
1.Support.
2.Insulation
3.Phagocytosis
4.Actively dividing.
5.They do not form synapse.
Types
1.Astrocytes:= *Star shaped, *Has number of processes, *Located in
brain and grey matter.
2.Oligodendroglia = has fewer short processes, Nucleus with cytoplasm,
Location= Medullary nerve fibers
3.Microglia = Smallest glial cell, Located in grey matter, Phagocytic in
nature.
Ependermal cells (=Ependyma)
They form epithelium that lines the cavity in the brain ventricles and spinal
cord (central canal) which absorb CSF, and help in movement of CSF. They
are ciliated.
Neurosecretory cells
Action potential or Impulse: The potential difference between outside and inside of membrane of
neuron during depolatized state.
1st phase: Na pump is closed. No farther entry of Na ions. K-ions are efluxed and initially
established a outside positive and inside negative.
2nd Phase: Na-K pump slowly re-establish the polarized state i.e. Na concentration is
higher in outside and K- inside.
This phases are known as Repolarized state.
The resting membrane
potential slowly established
using Na+-K+ pump by which
Na+ ions move out and K+
move in from outside of
nerve cell. The entire
process of repolarization
requires some time during
which the nerve cannot be
stimulated again. This
period is known as
refractory period.
K+ ion channels remain open for a bit longer period during repolarization that enhance K ion
eflux for longer period,so that the membrane potential becomes more negative than -70 mV.
It is called hyperpolarisation.
Mechanism of transmission of nerve impulse through neuron
ECF = Extracellular fluid Na+ concentration higher
Out side of the cell
ICF = Intracellular
fluid= inside of cell Na+ concentration lower
Polarized state :
In resting state of neuron, Out side of the cell is positively charged due to
higher concentration of Na+ ions and inside is relatively negatively
charged due to less concentration of Na+ inside of the cell.
Na+ - channel
Depolarized state: Due to appearance of stimulus, Na+ channel opens as a result Na+ enters from
outside of the cell to inside which makes the outside of the cell negatively charged and inside of the
cell positively charged. This state of the cell is called depolarized state.
Refractory period: If two successive stimuli of more than threshold intensity are
applied to a nerve, the nerve is unable to respond to the second stimulus for
quite some time i.e. the nerve has become refractory to subsequent stimulation.
Synapse
What is Synapse?
Types of synapse:
Structure of Chemical Synapse
Synapse is the point of contact between the terminal branches of the axon
of a neuron with the dendrites of another neuron separates by a fine gap.
Structure of synapse
Pre-synaptic membrane
Post-synaptic membrane
synaptic membrane
Receptor
Synaptic Delay: The time taken for an impulse to cross a synapse is called synaptic delay.
Synaptic fatigue: It is a temporary suspension of impulse transmission in the region of synapse due
to exhaustion of its neurotransmitter.
1. Na ions move from A to B.
2. Na ions in B section
stimulate the entry of Na
ions.
3. + ve charge also moves
from A to B inside of the
membrane and + ve charge
out side of the membrane
move from B to A.
4. As a result action potential
conducted from A to B
section of neuron.
Which of the following is the main ion involved in nerve impulse
transmission
(a)Ca2+ (b) Na +© Mg2+ (d) K+
Which of these is an excitatory neurotransmitter in brain
a.GABA
b.Glycine
c.Glutamate
d.Acetylcholine
Which of these is an excitatory neurotransmitter in neuro-mascular
junction
a.Epnephrine
b.Glycine
c.Glutamate
d.Acetylcholine
- - - - - - - - - - - - - -
+
[K ] [N a +] [A - ]
IC F (1 5 m M ) A xon
(1 5 0 m M ) (1 0 0 m M )
- - - - - - - - - - - - - - Segm en t
+ + + + + + + + + + + + + + +
High concentration of Na+, Ca 2+ and Cl- ions out side the cell.
Membrane of neuron is highly impermeable to Na+, Cl- ions, less to Ca 2+ and permeable to K+ and
also impermeable to organic ions (A-).
+ + + + + - - - - - - - - -
A xon
+ + + + + - - - - - - - - -
Segm en t
- - - - - - - + + + + + + + + +
+ + + + + - - - - - - - - -
A xon
+ + + + + - - - - - - - - - Segm en t
- - - - - - - + + + + + + + + +
Step-II
1 s t A ction P oten tial 2 n d A ction P oten tial
+
K.
+ + + + + - - - - - + + + +
- - - - - - - - - - - -
+
K.
A xon
- - - - - - + + + + - - - -
Segm en t
+ + + + - - - - - + + + + +
+
K.
Step-III
2n d A ction P oten tial 3r d A ction P oten tial
+
K.
+ + + + + + + + + - - - - - - +
- - - - - - - - + + + + - -
+
K. A xon
- - - - - - - - - + + + + - -
Segm en t
+ + + + + + + + - - - - - - - + +
+
K.
Nervous system
Nervous System
Sympathetic Parasympathetic
System System
Brain
Corpora quadrigemina
Functions:
Controls visual & Auditory reflexes
Crura cerebri
Functions:
Co-ordination between hind & forebrain
Epithalamus
Pineal gland
Olfactory lobe
Cereballum
Pituitary gland
Arbour vitae
Mammillary body
Pons
Spinal cord
Medulla oblongata
The human cerebral cortex.
Each side of the cerebral cortex is divided into four lobes, and each lobe has
specialized functions, some of which are listed here. Some areas on the left side
of the brain (shown here) have different functions from those on the right side (not
shown).
Mention the name of cerebral lobe and their major functions.
Frontal lobe Inner monitoring of complex thoughts and action, creative ideas, translation of
perceptions and memories into plans of muscle movement, reality testing by
judgement, intellectual insight, ability to abstract, reasoning, decision making,
expression of emotions, willpower and personality.
Parietal lobe Registration of sensory perception of touch, pain, heat and cold, knowledge
about position in space, taking in information from environment, organising it
Temporal lobe
Decoding and interpretation of sound,language comprehension, smell,
memory and emotion.
Occipital lobe Decoding and interpretation of visual information shape and colour.
Limbic System
•Limbic System
Flared like a wish bone a ring or fork, through extensive
neural links with the cerebrum and the brain stem below,
constitute what is called limbic (meaning lip-like) system.
This system sends out signals to the rest of the brain and
the body which have great effect on human behavior (thus
called ‘emotional brain’).
Limbic system includes hypothalamus, amygdala,
hippocampus, septum, anterior nucleus of thalamus
and portion of basal ganglia.
•Amygdala
almond-shaped structure located above the
hypothalamus, attached to the interior lips of both forks of
limbic system, is called amygdala. This bulge of neurons
is like a defense castle controlling the moods, especially
anger and rage. Various regions of the amygdala play
important role in emotional behaviour, such as aggression
and remembering fear.
•Hippocampus
Taking its name from the Greek for "sea horse". whose
shape roughly resembles, the hippocampus make the
swollen lower lip of the limbic fork. The remarkable organ
deals with a strange mix of signals about smells and
memories. The hippocampus functions as a kind of index
for recall of an event its associated memory. The
hippocampus converts information from short-term to long-
term memory, essential in learning.
•Limbic System
Flared like a wish bone a ring or fork, through extensive neural links with the
cerebrum and the brain stem below, constitute what is called limbic (meaning
lip-like) system. This system sends out signals to the rest of the brain and the
body which have great effect on human behavior (thus called ‘emotional
brain’).
Limbic system includes hypothalamus, amygdala, hippocampus, septum,
anterior nucleus of thalamus and portion of basal ganglia.
•Basal Ganglia
The inside of human brain is not so densely packed, but there are all kinds of different collections of
neurons, called nuclei, each with its specific functions. These control different body activities
automatically. Basal ganglia is a collection of subcortical nuclei in the forebrain, at the base of the
cortex. The largest nucleus in it is the corpus striatum.
Main Parts of Basal Ganglion: (i) Putament (ii) Globus pallidus (iii) Caudate nucleus (iv)
Amygdaloid nucleus (v) Claustrum.
Function: It regulates planning and execution of stereotyped movements. Other basal ganglia perform at
subconscious level learned pattern of movements like slow and fast pedalling; slow and fast writing/typing
etc.
•arbor vitae
A cross section of the cerebral hemisphere
shows branching tree-like arrangement of
grey and white matter is called arbor vitae.
•Basal Ganglia
The inside of human brain is not so densely packed, but
there are all kinds of different collections of neurons,
called nuclei, each with its specific functions. These
control different body activities automatically. Basal
ganglia is a collection of subcortical nuclei in the
forebrain, at the base of the cortex. The largest nucleus in
it is the corpus striatum. It regulates planning and
execution of stereotyped movements. Other basal ganglia
perform at subconscious level learned pattern of
movements like slow and fast pedalling; slow and fast
writing/typing etc.
Midbrain = Mesencephalon
1.Corpora quadrigemia
---- Superior colliculi-- receive impulses from eye, muscles of the
head and control visual reflexes
Inferior colliculi – Receives sensory impulses from ear –
Controls auditory reflexes
2. Cerebral peduncles – relay impulses between cerebrum and
cerebellum
State the functions of following parts of brain
1.Lobes of cerebral cortex – Frontal, temporal, occipital and parietal.
2.Cerebrum
3.Corpus callosum
4.Hypothalamus
5.Thalamus
6.Basal ganglia
7.Midbrain
8.Pons varolli
9.Medulla oblongata Vermis
10.Limbic system
11.Hippocampus
12.Amygdala.
Different parts of cerebral cortex
Parts Lobe Function
Pre-frontal cortex Frontal Intelligence, Memory, Thought == Organ of mind
Pre-motor area Frontal Writing centre and writing related movement of eye
Neurotransmitters are the chemicals released from a presynaptic neuron that interact
with specific receptor sites of a postsynaptic neuron which help in transmission of
impulse.
Inhibitor of pain
pathway of spinal cord
Excitatory Inhibitory Neurotransmitter
Neurotransmitter
1. Acetylcholine (except in 1. GABA
heart)
2. Glutamate 2. Glycine
3. Epinephrine 3. Dopamine
4. Norepinephrine 4. Serotonin
Meninges (singular Meninx)
Pia matter
Inner layer
Delicate, transparent Vascular membrane
Ventricles of Brain
The ventricles consist of four hollow, fluid filled spaces inside the brain.
Ventricles of Brain
The ventricles consist of four hollow, fluid filled spaces inside the brain.
Cerebro Spinal Fluid (CSF)
Functions
1.Mechanical buffer : Remaining inside and outside the central Nervous
system CSF equalises mechanical pressure between brain and cranium.
2.Nutrition and O2 : It supplies nutrition and 02 to nerve cells.
3.Removal of metabolic wastes : It removes metabolic wastes from
central nervous system.
4.Protection : Lymphocyte cells in CSF protect brain and nerve cells from
the attack of germs.
Process of formation : (i) Filtration and (ii) Active secretion.
It is formed from blood capillaries and returned to blood by way of
veins. The rate of formation is 20 ml per hour and 500 ml per 'day in
adults.
Composition
Somatic nerves
1.Spinal nerves
2.Cranial nerves
Cervical Nerves ------------------- 8 pairs
Thoracic Nerves ------------------- 12 pairs
Lumber Nerves -------------------- 5 pairs
Sacral Nerves ----------------------- 5 pairs
Coccygeal Nerves ------------------ 1 pair
1st Olfactory olfactory lobe sensory olfactory epithelium in nasal cavity smell
4th Trochlear floor of midbrain motor superior oblique muscle of eye ball rotation of eye ball
6th Abducens ventral side of medulla motor external rectus muscle of eye ball rotation of eye ball
7th Facial side of medulla mixed taste buds, salivary glands, facial and taste, facial expression, saliva secretion,
neck muscles neck movements
12th Hypoglossal ventral side of medulla motor muscles of tongue tongue movements
Receptors
(ii) For Heat High temp. (25 - 40°C) Ruffini's organs in skin
Autonomic nervous system
Nerve
tract