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    Group 5

    Uploaded by

    JACOB ZANU

    Copyright:

    © All Rights Reserved
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    Group 5

    Uploaded by

    JACOB ZANU
    1 views8 pages

    Original Title

    GROUP 5

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    1 views8 pages

    Group 5

    Uploaded by

    JACOB ZANU

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 8

    Factors affecting drug responsiveness

    Dietary factors

    1
    Introduction

    Response to drugs vary from person


    to person. The way a person
    responds to a drug is affected by
    many factors, including;
    • Age
    • Genetics
    • Weight
    • Disease condition
    • Dietary
    2
    Introduction

    Food-drug interactions occur when food or one of its components


    interferes with the effect of a drug in the body.

    Foods contain active substances that interact against certain medications


    to produce unwanted or unexpected effects.

    Certain foods when ingested together with certain drugs, may affect the
    overall bioavailability, pharmacokinetics, pharmacodynamics and
    therapeutic efficacy of the medications.

    Presence or absence of some nutrients in the gastrointestinal tract and/or


    in the body’s physiological system, such as in the blood, can enhance, 3
    Dietary influence on dug
    responsiveness
    Some foods attenuate drug effects by interfering with drug actions,
    mechanisms and the pharmacodynamics of the drug.
    Examples of such interactions are as follows:

    Vitamin K and warfarin interactions

    Iodine rich foods and thyroid drugs

    Calcium and tetracycline


    4
    Dietary influence on dug
    responsiveness
    On the other side, some foods enhance drug effects or provides
    beneficial effects. Examples of such interactions are as follows:

    Caffeine and theophylline interaction

    High fat foods and lipid soluble drugs. Eg. ARV


    protease inhibitors like saquinavir. Griseofulvin.

    Vitamin C rich foods enhance absorption of iron


    based drugs
    5
    Dietary influence on drug
    responsiveness

    6
    Conclusion

    Drugs taken orally are absorbed


    through the lining of the stomach or
    the small intestine just like food.

    However, the presence of food in the


    digestive tract may reduce or affect
    the absorption of a drug.

    Thus drugs should be taken


    sometime before or after eating
    depending on prescription. 7
    References

    Choi JH, Ko CM. (2017). Food and Drug Interactions. J Lifestyle


    Med; 7(1):1-9. doi: 10.15280/jlm.2017.7.1.1

    Niederberger, E., & Parnham, M. J. (2021). The impact of diet and


    exercise on drug responses. International journal of molecular
    sciences, 22(14), 7692.

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