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    Favorskiirearrangementoct 130921133027 Phpapp01

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    Favorskiirearrangementoct 130921133027 Phpapp01

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    muhammad ijaz
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    4 views8 pages

    Favorskiirearrangementoct 130921133027 Phpapp01

    Uploaded by

    muhammad ijaz

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
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    Organic Chemistry for technologist II

    Favorskii
    Rearrangement
    By Sagar Divetiya
    Environment science and technology (4th sem)
    110990135013
    Outline 2

    • Principle

    • Some reactions

    • Mechanism ( Cyclic Ketone )

    • Mechanism ( Open chain Ketone )

    • Applications

    Prepared by Sagar Divetiya 19/11/2024 06:49 PM


    Principle 3

    • α-Halogenated ketone undergoes rearrangement in


    the presence of a base like hydroxide, alkoxide or
    amine to give a carboxylic acid or its derivative i.e.
    ester, amide. The reaction is known as Favorskii
    rearrangement.

    • The halogen may be a chloride, bromide or iodide.


    Este

    α- Alkoxide
    r 4
    halogenated
    Este
    Hydroxid r
    e

    Carboxylic
    acid Some
    reactions
    Carboxylic
    acid

    Keton
    e
    Prepared by Sagar Divetiya 19/11/2024 06:49 PM
    Mechanism ( Cyclic Ketone ) 5

    Cl O

    1 H
    R
    O
    -H
    Cl O

    2 - Cl
    O

    3 R
    O
    Re F
    a r a vo
    ra rs
    ng k
    t em i i
    en

    4
    O O O

    5
    H
    O R
    R
    R H
    Prepared by Sagar Divetiya
    O 19/11/2024 06:49 PM
    Mechanism ( Open Chain
    Ketone) 6

    2
    O

    1
    R’ RO R’

    3
    O
    R’
    H X X
    RO
    Favorskii
    Rearrangeme
    nt

    4
    O O

    5
    O O
    O

    6
    O R
    R R
    R’ R’
    R H
    R’ H O
    Prepared by Sagar Divetiya 19/11/2024 06:49 PM
    Applications 8

    Prepared by Sagar Divetiya 19/11/2024 06:49 PM


    Applications 9

    Prepared by Sagar Divetiya 19/11/2024 06:49 PM

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