Scribd
Upload
10 views

Complement System

Uploaded by

mncknnn
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
10 views

Complement System

Uploaded by

mncknnn
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 18

Complement system

Dr Niveditha
 Collection of soluble proteins and
membrane receptors
 Host defense against microbes
 C1 to C9
 Functions in both innate and
adaptive immunity
 Classical
 Alternative
 Lectin
Stages of complement
activation
 Intiation of the pathway
 Formation of C3 convertase
 Formation of C5 convertase
 Formation of MAC
Classical pathway

 Classsical pathway is Ab dependent


 IgM and IgG can bind to to
complements
 Intiation - Binding of C1 to Ag-Ab
complex
 C1q binds to with Fc portion OF IgM/
IgG
 C1s acts as esterase which cleave C4
to C4a and C4b , further complement
cascade , C14b2a – C3 convertase
Classical pathway
Alternate pathway

 Independent of antibody
 Part of innate immunity
 Requires serum proteins - factor B,
factor D and properdin
 C3 in serum hydrolyses
spontaneously – C3a,C3b
 C3b attaches to the surface of
antigen
Alternate pathway

 Factor B binds with C3b coated


foreign cells
 Factor D acts on factor B and cleaves
into Ba (diffuses) and Bb
 C3bBb is C3 convertase
Lectin pathway

 Ab Independent
 Mediated through lectin proteins of
host that interact with mannose
residues on microbial surface
 MBL is acute phase reactant protein ,
similar to C1q
 MBL associated serine protease
(MASP) gets complexed with MBL
Lectin pathway
Functions of complement
system
 Inflammation - C3a, C5a
 Opsonisation and phagocytosis –
C3b, C4b
 Cell lysis – MAC complex C5-9
Regulation of complement
pathways
 Complement systems are antigen
non specific
 Capable of attacking host cells
 Several regulatory mechanisms are
evolved to regulate their activity
 C1 INH
 DAF (decay accelerating factor)
C1 INH / C1 esterase
inhibitor
 Soluble glycoprotein
 Inhibits the action of C1q
 Classical pathway is inhibited
 Hereditary angioneurotic edema
DAF

 CD55 molecule
 Present on cell membrane
 Accelerates dissociation of C3
convertase
 Inhibits all three pathways
Complement deficiencies

You might also like