Vaccines

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VACCINES AND

IMMUNIZATION
SCHEDULE
MS.MANSI BAJANIYA
VACCINES

• “ANY PREPARATION INTENDED TO GENERATE IMMUNITY


AGAINST DISEASE BY STIMULATING THE PRODUCTION OF
ANTIBODIES WHICH CAN BE A SUSPENSION OF KILLED OR
ATTENUATED MICRO ORGANISMS OR PRODUCTS OR
DERIVATIVESBOD MICRO ORGANISMS.”
TYPES OF VACCINES

• INACTIVATED VACCINES
• LIVE-ATTENUATED VACCINES
• MESSENGER RNA (MRNA) VACCINES
• SPECIFIC VACCINES
• TOXOID VACCINES
 INACTIVATED VACCINES
• Inactivated vaccines use the killed version of the germ that causes a
disease.
• Inactivated vaccines usually don’t provide immunity (protection) that’s as
strong as live vaccines. So you may need several doses over time
(booster shots) in order to get ongoing immunity against diseases.
• Inactivated vaccines are used to protect against:
• Hepatitis A
• Flu (shot only)
• Polio (shot only)
• Rabies
 LIVE ATTENUATED VACCINE
• LIVE VACCINES USE A WEAKENED (OR ATTENUATED) FORM OF
THE GERM THAT CAUSES A DISEASE.
• BECAUSE THESE VACCINES ARE SO SIMILAR TO THE NATURAL
INFECTION THAT THEY HELP PREVENT, THEY CREATE A
STRONG AND LONG-LASTING IMMUNE RESPONSE.
• JUST 1 OR 2 DOSES OF MOST LIVE VACCINES CAN GIVE YOU A
LIFETIME OF PROTECTION AGAINST A GERM AND THE
DISEASE IT CAUSES.
• THEY PROVIDE LONG TIME AND STRONG IMMUNITY.
EXAMPLES
• Live vaccines are used to protect against:
• Measles, mumps, rubella (MMR combined vaccine)
• Rotavirus
• Smallpox
• Chickenpox
• Yellow fever
 MESSENGER RNA (MRNA) VACCINES

• THE VACCINES PREPARED FROM THE MICROBIAL m RNA ARE


KNOWN AS THE MRNA VACCINES.
• THEY FROM PROTEINS THAT HELP IN GENERATING
PROTECTION FROM THE DISEASE.
• EXAMPLE…..
• COVID-19 VACCINES
 SPECIFIC VACCINES

• THESE INCLUDE VACCINES LIKE THE


SUBUNIT,RECOMINANT,POLYSACSCCHARIDE AND CONJUGATE
VACCINES.
• THEY ARE PREPARED BY A PARTICULAR MATERIAL COMPONENTS OF
THE MICROBES LIKE SUGAR MOLECULES OR PRITIEN ETC….
• EXAMPLES…
• HAEMOPHILUS INFLUENZAE TYPE B
• HUMANPEPILLOMAVIRUS (HPV)
• HEPATITIS B VACCINES…
 TOXOID VACCINES

• TOXOID VACCINES USE A TOXIN (HARMFUL PRODUCT) MADE BY THE GERM THAT CAUSES A
DISEASE.
• THEY CREATE IMMUNITY TO THE PARTS OF THE GERM THAT CAUSE A DISEASE INSTEAD OF THE
GERM ITSELF.
• THAT MEANS THE IMMUNE RESPONSE IS TARGETED TO THE TOXIN INSTEAD OF THE WHOLE
GERM.
• EXAMPLES

• DIPHTHERIA
• TETANUS
STORAGE AND HANDALING
• The storage and handling of the vaccines must be according to the
standard operating procedures (SOPs) only in all facilities. The SOPs for
the same must be planned considering the following key features:….
• The general information regarding the batch of the particular vaccine
must be easily available and should include the information about the
manufacturer, the service providers for the equipment, the key staff
members of the facility along with their job descriptions, the forms
used daily as well as the requirements for training the staff.
• The information related to the inventory management of the vaccines
covering the routine storage as well as handling must be covered in
the SOPs
VACCINE FLOW
COLD CHAIN

DEFINATION
• THE 'COLD CHAIN' IS A SYSTEM/NETWORK THAT EXPLAINS
THAT HOW A VACCINE MUST BE STORED AND TRANSPORTED
FROM ITS MANUFACTURING SITE TO THE SITE OF ITS ACTUAL
USAGE CONSIDERING THE RECOMMENDED RANGE OF THE
TEMPERATURE AT WHICH IT MUST BE CONTAINED OR CARRIED.
• THE POTENCY OF THE VACCINE IF LOST ONCE CANNOT BE
RESTORED BACK.
VACCINE DELIVERY FEATURES
• THE QUANTITY OF THE VACCINE DELIVERED MUST BE RIGHT.
• THE QUALITY OF THE VACCINE DELIVERED MUST BE RIGHT.
• THE DELIVERY TIME OF THE VACCINE MUST BE RIGHT.
• THE TEMPERATURE AT WHICH THE VACCINES NEED TO BE
DELIVERED OR STORED DURING THE TRANSPORT MUST BE RIGHT.
• THE PLACE TO WHICH THE VACCINES NEED TO BE DELIVERED
MUST BE RIGHT.
• THE BENEFICIARY TO WHICH THE VACCINES MUST REACH OUGHT
TO BE RIGHT.
COLD CHAIN EQUIPMENTS

1)ELECTRICAL STORAGE EQUIPMENTS


EX…WALK IN FREEZER ,WALK IN COOLER ,DEEP FREEZER
2)SOLAR REFRIGERATOR
3)NON ELECTRICAL REFRIGERATOR
EX…COLD BOX
VACCINE CARRIER
WALK IN COOLER WALK IN FREEZER DEEP FREEZER
VACCINE SENSITIVITY
• The vaccines are sensitive to heat, light and freezing. The
sensitivity of some of the vaccines are as follows:
• Heat sensitive but freeze stable vaccines-oral polio vaccine
(OPV) and measles-mumps-rubella (MMR).
• Light sensitive but freeze stable vaccines-MMR, bacillus
calmette guerin (BCG), Rotavirus vaccine (RVV) and Japanese
encephalitis (JE).
• Freeze sensitive but heat stable vaccines-Hepatitis B/Penta
vaccine, inactivated poliovirus vaccine (IPV), tetanus toxoid
(TT) and diphtheria, pertussis, and tetanus (DPT).
IMMUNIZATION SCHEDULE
VACCINE WHEN TO GIVE DOSE ROUTE SITE

FOR PREGNANAT
WOMAN

TETANUS TOXOIED EARLY IN 0.5 ML INTRAMUSCULAR UPPER ARM


(TT-1) PREGNANCY

TT-2 4 WEEKS AFTER 0.5 ML INTRAMUSCULAR UPPER ARM


PREGNANCY
TT-BOOSTER IF RECEVED 2 TT 0.5 ML INTRAMUSCULAR UPPER ARM
DOSE IN A
PREGNANCY
WITHIN LAST 3
YEARS
VACCINE WHEN TO GIVE DOSE ROUTE SITE
FOR INFANT
BCG AT BIRTH OR AS 0.1 ML (0.05 ML ID LEFT UPPER ARM
EARLY AS UNTILL 1 MONTH
POSSIBE TILL 1 OF AGE )
YEAR OF AGE
HEPATITIS B AT BIRTH OR AS 0.5 ML IM ANTEROLATERAL
BIRTH DOSE EARLY AS SIDE OF MID
POSSIBE WITH IN THIGH
24 HOURS

OPV – 0 AT BIRTH OR AS 2 DROPS ORAL ORAL


EARLY AS
POSSIBE WITHIIN
THE FIRST 15
DAYS

OPV – 1,2,3 AT 6,10,14 2 DROPS ORAL ORAL


WEEKS
DP 1,2,3 AT 6,10,14 0.5 ML IM ANTEROLATERAL
WEEKS SIDE OF MID
THIGH
VACCINE WHEN TO DOSE ROUTE SITE
GIVE
MEASELES -1 9 MONTH 0.5 ML SUBCUTENEOUS RIGHT UPPER ARM
COMPLETED
MONTHS-12
MONTH (TILL 5 YR
OF AGE)
RVV 6,10,14 WEEKS 5 DROPS ORAL ORAL

FIPV 6,10,14 WEEKS 0.1 ML ID UPPER ARM

PCV 6,14 WEEK ,9-12 0.5 ML IM ANTEROLATERAL


MONTHS ASPECTS OF MID
THIGH
JAPANESE 9 MONTH 0.5 ML SUBCUTENEOUS LEFT UPPER ARM
ENCEPHELITIS COMPLETED
MONTHS-12
MONTH
VIT A (1ST DOSE) AT 9 COMPLETED 1 ML ( 1 LK IU) ORAL ORAL
MONTH WITH
VACCINE WHEN TO DOSE ROUTE SITE
GIVE
FOR CHILDREN

DPT BOOSTER -1 16-24 MONTHS 0.5 ML IM ANTERIOLATERAL


SIDE OF MID
THIGH
MEASLES 2ND 16-24 MONTHS 0.5 ML SUBCU RIGHT UPPER ARM
DOSE
OPV BOOSTER 16-24 MONTHS 2 DROPS ORAL ORAL

JAPANESE 16-24 MONTHS 0.5 ML SUBCU LEFT UPPER ARM


ENCEPHALITIS
VIT A BOOSTER 16 MONTH. THEN 2 ML (2 LK IU) ORAL ORAL
(2ND DOSE TO 9TH ONE DOSE EVERY
DOSE ) 6 MONTH UP TO
AGE OF 5 YRS
DPT BOOSTER – 2 5 – 6 YEARS 0.5 ML IM UPPER ARM

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