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Final Presentation

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Jamila Hamdi
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15 views21 pages

Final Presentation

Uploaded by

Jamila Hamdi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Drug Persistency Project

Virtual Internship: Final Presentation

Group Name: Health+


Group Members:
Mohammad Odeh (United Arab Emirates)
Sakib Mahmud (Qatar)
Date: 11-May-2021
Background – Drug Persistency case study

 One of the challenge for all Pharmaceutical companies is to understand the persistency of drug as per the
physician prescription. To solve this problem ABC pharma company approached an analytics company to
automate this process of identification.
 Objective : Gather insights on the factors that are impacting the persistency, build a classification for the
given dataset.
The analysis has been divided into three parts:
• Data Understanding
• Data insights and visualization
• Recommendations
Data Exploration
• 68 Features, including :
• General features such as (Demographics, Provider Attributes)
• Diseases/Drugs Factors
• Clinical Factors

• Total number of patients : 3424

Assumptions:

 The data follows Normal Distribution.


 Patients’ history data were recorded accurately without any errors in testing or examination.
Demographics
Profit Analysis Analysis

Gender Proportion Gender Proportion vs. Persistency Flag


Demographics
Profit Analysis Analysis

Age Proportion Age Bucket vs. Persistency Flag


Demographics
Profit Analysis Analysis

Ethnicity Proportion Ethnicity vs. Persistency Flag


Demographics
Profit Analysis Analysis

Region Proportion Region vs. Persistency Flag


Demographics
Profit Analysis Analysis

Race Proportion IDN Indicator Ratio


Disease Type and Responsible Physician
Specialty Analysis
Drug Factor Analysis

Concomitancy of Drugs
Diseases Factor Analysis

Comorbidity of Diseases
Risk Factor Analysis

Risk Factors
Risk Factor Analysis

• High number of non persistent


patients has less than 3 count of
risks.
• Patients with more than 3 count
of risks has the highest
percentage of non-persistent
cases compared to total
registered cases.

Risk Counts Vs Persistency Flag


Risk Factor Analysis

• High number of non persistent


patients has less than 3 count of
risks.
• Patients with more than 3 count
of risks has the highest
percentage of non-persistent
cases compared to total
registered cases.

Risk Counts Vs Persistency Flag


Dominance Analysis
• Dominance Analysis show most
influential features in the data
set (Most 15 influential factors).

• It can be noticed that clinical


parameters were the most
influential factors behind
persistency of drugs.
Recommendations
From the Exploratory Data Analysis (EDA) done on the dataset, following recommendations are given to the ABC
company’s technical team:
 Demographic Factors provided in the dataset is not strongly related to the “Persistency Level” of the patients.
 NTM Specialist type or Specialist Flag did not show any correlation to the target variable.
 Some important parameters were determined using Dominance Analysis which can be used to transform the
dataset into a subset and perform quantitative analysis.
 Clinical Factors such as “Concomitancy of Drugs”, “Comorbidity of Various Diseases” and “Risk Factors” do
show some correlations with the target variable “Persistency Level” of the patients which needs to be
investigated further through a Quantitative Analysis such as Machine Learning.
Recommendations
Original Autoencoder Dominance Analysis
ML Algorithms MAE Accuracy Precision Recall f1-Score AUC MAE Accuracy Precision Recall f1-Score AUC MAE Accuracy Precision Recall f1-Score AUC
Logistic Regression 0.19 0.81 0.81 0.79 0.81 0.88 0.20 0.80 0.79 0.78 0.79 0.87 0.27 0.73 0.73 0.68 0.72 0.76
K-Nearest Neighbour (KNN) 0.22 0.78 0.78 0.73 0.76 0.84 0.21 0.79 0.80 0.78 0.79 0.83 0.31 0.69 0.68 0.63 0.67 0.70
Support Vector Machine (SVM) 0.21 0.79 0.78 0.76 0.78 0.86 0.20 0.80 0.80 0.79 0.80 0.82 0.28 0.72 0.72 0.69 0.72 0.71
Stochastic Gradient Descent (SGD) 0.24 0.76 0.76 0.75 0.76 0.81 0.21 0.79 0.80 0.79 0.79 0.86 0.28 0.72 0.71 0.67 0.71 0.74
Decision Tree 0.27 0.73 0.73 0.71 0.73 0.71 0.25 0.75 0.75 0.73 0.75 0.73 0.35 0.65 0.63 0.59 0.63 0.62
Gradient Boosting 0.19 0.81 0.81 0.78 0.81 0.88 0.20 0.80 0.80 0.79 0.80 0.86 0.28 0.72 0.71 0.68 0.71 0.76
Random Forest 0.19 0.81 0.80 0.78 0.80 0.88 0.22 0.78 0.78 0.76 0.78 0.84 0.33 0.67 0.66 0.63 0.66 0.69
Extra Trees 0.21 0.79 0.79 0.77 0.79 0.87 0.23 0.77 0.77 0.75 0.77 0.84 0.34 0.66 0.64 0.60 0.64 0.67
AdaBoost 0.19 0.81 0.81 0.79 0.81 0.87 0.21 0.79 0.79 0.78 0.79 0.86 0.28 0.72 0.72 0.67 0.71 0.75
XgBoost 0.21 0.79 0.80 0.75 0.78 0.87 0.20 0.80 0.80 0.79 0.80 0.86 0.28 0.72 0.71 0.66 0.70 0.76
Multiple Layer Perceptron (MLP) 0.25 0.75 0.75 0.74 0.75 0.82 0.21 0.79 0.79 0.77 0.79 0.86 0.32 0.68 0.68 0.65 0.68 0.70
ANN Developed with KERAS 0.80 0.78 0.79 0.79
Recommendations
Recommendations
Recommendations
Based on the provided data ( mostly categorical ), and the previous analysis we recommend 2 types of model to
build for this problem:
 Neural Networks
 Adaptive Boosting (Ensemble)
 Gradient Boosting (Ensemble)

Both should be complex enough to learn well the data and provide high accuracy

Selected Pipeline: Autoencoder based feature extraction


Thank You

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