Seizure Updated ILAE Classification

ILAE Seizure Classification
The International League against Epilepsy (ILAE) Commission on Classification and Terminology, 20052009 has provided an updated approach to classification of seizures. Based on: clinical features of seizures associated electroencephalographic findings.
Etiology or cellular substrate are not considered in this classification system.
Focal seizures arise from a neuronal network either discretely localized within one cerebral hemisphere or more broadly distributed but still within the hemisphere. With the new classification system, the subcategories of "simple focal seizures" and "complex focal seizures" have been eliminated. Instead, depending on the presence of cognitive impairment, they can be described as focal seizures with or without dyscognitive features.
Focal seizures can also evolve into generalized seizures. In the past this was referred to as focal seizures with secondary generalization, but the new system relies on specific descriptions of the type of generalized seizures that evolve from the focal seizure. The routine interictal (i.e., between seizures) electroencephalogram (EEG) in patients with focal seizures is often normal or may show brief discharges termed epileptiform spikes, or sharp waves. Since focal seizures can arise from the medial temporal lobe or inferior frontal lobe (i.e., regions distant from the scalp), the EEG recorded during the seizure may be nonlocalizing.
Focal Seizures Without Dyscognitive Features

motor, sensory, autonomic, or psychic symptoms without impairment of cognition. movements are typically clonic at a frequency of 23 Hz. Three additional features of focal motor seizures:
Abnormal motor movements may begin in a very restricted region such as the fingers and gradually progress (over seconds to minutes) to include a larger portion of the extremity, known as a "Jacksonian march," represents the spread of seizure activity over a progressively larger region of motor cortex. Localized paresis (Todd's paralysis) for minutes to many hours in the involved region following the seizure. Seizure may continue for hours or days, epilepsia partialis continua, is often refractory to medical therapy.
Focal seizures may also manifest as changes in somatic sensation (e.g., paresthesias), vision (flashing lights or formed hallucinations), equilibrium (sensation of falling or vertigo), or autonomic function (flushing, sweating, piloerection). Focal seizures arising from the temporal or frontal cortex may also cause alterations in hearing, olfaction, or higher cortical function (psychic symptoms). sensation of unusual intense odors (e.g., burning rubber or kerosene) or sounds (crude or highly complex sounds) an epigastric sensation that rises from the stomach or chest to the head. Some patients describe odd, internal feelings such as fear, a sense of impending change, detachment, depersonalization, dj vu, or illusions that objects are growing smaller (micropsia) or larger (macropsia).
Focal Seizures with Dyscognitive Features

transient impairment of the patient's ability to maintain normal contact with the environment. The patient is unable to respond appropriately to visual or verbal commands during the seizure and has impaired recollection or awareness of the ictal phase. The seizures frequently begin with an aura that is stereotypic for the patient. The start of the ictal phase is often a sudden behavioral arrest or motionless stare, which marks the onset of the period of impaired awareness.
Automatisms--involuntary, automatic behaviors that have a wide range of manifestations. (chewing, lip smacking, swallowing, or "picking" movements of the hands, or more elaborate behaviors such as a display of emotion or running.) Confused following the seizure Transition to full recovery of consciousness may range from seconds up to an hour Anterograde amnesia or, in cases involving the dominant hemisphere, a postictalaphasia.
Evolution of Focal Seizures to Generalized Seizures

Spread to involve both cerebral hemispheres and produce a generalized seizure, usually of the tonic-clonic variety. Focal seizures arising from a focus in the frontal lobe, but may also be associated with focal seizures occurring elsewhere in the brain.
Generalized Seizures
Typical Absence Seizures (symmetric, 3-Hz spikeand-wave discharge) Atypical Absence Seizures (slow spike-and-wave pattern with a frequency of 2.5/s) Generalized, Tonic-Clonic Seizures Atonic Seizures Myoclonic Seizures
Currently Unclassifiable Seizures

Epileptic spasms
briefly sustained flexion or extension of predominantly proximal muscles, including truncal muscles. EEG: hypsarrhythmias, which consist of diffuse, giant slow waves with a chaotic background of irregular, multifocal spikes and sharp waves. During the clinical spasm, there is a marked suppression of the EEG background (the "electrodecremental response"). Electromyogram (EMG): rhomboid pattern that may help distinguish spasms from brief tonic and myoclonic seizures. Epileptic spasms occur predominantly in infants and likely result from differences in neuronal function and connectivity in the immature versus mature CNS.

Seizure Updated ILAE Classification

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What are the different types of focal seizures?

What are the characteristics of focal seizures with dyscognitive features?

ILAE Seizure Classification

Etiology or cellular substrate are not considered in this classification system.

Focal Seizures Without Dyscognitive Features

Focal Seizures with Dyscognitive Features

Evolution of Focal Seizures to Generalized Seizures

Currently Unclassifiable Seizures

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