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    NSAIDs

    Uploaded by

    Sujan Dahal

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    © All Rights Reserved
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    NSAIDs

    Uploaded by

    Sujan Dahal
    6 views11 pages

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    © © All Rights Reserved

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    6 views11 pages

    NSAIDs

    Uploaded by

    Sujan Dahal

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 11

    NSAIDs

    • Nonsteroidal anti-inflammatory drugs


    (NSAIDs) are medicines that are primarily used
    to relieve pain, reduce inflammation, and
    decrease fever.
    Classification
    A. Nonselective COX inhibitors (traditional NSAIDs)
    1. Salicylic acid derivative: Aspirin, Sodium salicylate
    2. Propionic acid derivatives: Ibuprofen, Naproxen,
    Ketoprofen, Flurbiprofen
    3. Anthranilic acid derivative: Mefenamic acid,
    flufenamic acid
    4. Aryl-acetic acid derivatives: Diclofenac, Aceclofenac.
    5. Oxicam derivatives: Piroxicam, Tenoxicam.
    6. Pyrrolo-pyrrole derivative: Ketorolac
    7. Indole derivative: Indomethacin, Sulindac
    8. Pyrazolone derivative: henylbutazone,
    Oxyphenbutazone

    2
    B. Preferential COX-2 inhibitors :
    Nimesulide, Meloxicam, Nabumetone

    C. Selective COX-2 inhibitors:


    Celecoxib, Etoricoxib, Parecoxib.

    D. Analgesic-antipyretics with poor


    anti-inflammatory action
    1. Para aminophenol derivatives:
    Paracetamol
    2. Pyrazolone derivative: Metamizol,
    Propiphenazone.
    Paracetamol/Acetaminophen
    Chemistry
    • It is acetyl derivative of p-amino phenol.
    Physical properties
    • It occurs as white crystals or white crystalline
    powder.
    • It is odourless.
    • It has a slightly bitter taste.
    • It is slightly soluble in water but soluble in alcohol.
    • It's melting point is 169°C-170°C.

    Stability and storage


    • It is relatively stable in air but affected by light.
    Hence, it is stored in a well-closed light-resistant
    container.
    Uses
    It is used as –
    • Analgesic agent
    • Antipyretic agent
    • Anti-inflammatory agent.
    Ibuprofen
    Chemistry
    • It is propionic acid / propanoic acid derivative.
    • The propionic acid is attached with
    isobutylphenyl group.
    Physical properties
    • It is white crystal or crystalline powder with
    characteristics odour.
    • It is very slightly soluble in water but freely soluble
    in alcohol and soluble in an aqueous solution of
    alkali hydroxide.
    • It's melting point is 75°C-77°C.

    Stability and storage


    • It is affected by light and moisture. So, it is stored in
    a tightly closed light-resistant container.
    Uses
    It is used as –
    • Analgesic agent
    • Antipyretic agent
    • Anti-inflammatory agent.

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