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    Cutaneous Leishmaniasis: Caused by A Protozoa Called Leishmania Pathogenesis

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    Hudh Hud
    The document discusses cutaneous leishmaniasis, caused by the protozoa Leishmania. The disease is transmitted through the bite of infected sandflies. It presents with nodules, ulcers or dry plaques on exposed parts of the body. Diagnosis involves clinical examination, smear examination, skin biopsy, culture or other tests. Differential diagnoses include syphilis, deep mycosis, cutaneous tuberculosis and others. Treatment involves physical therapy, cryotherapy, heat therapy and drug therapy with medications like sodium stibogluconate, meglumine antimonate and others.

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    Cutaneous Leishmaniasis: Caused by A Protozoa Called Leishmania Pathogenesis

    Uploaded by

    Hudh Hud
    120 views30 pages
    The document discusses cutaneous leishmaniasis, caused by the protozoa Leishmania. The disease is transmitted through the bite of infected sandflies. It presents with nodules, ulcers or dry plaques on exposed parts of the body. Diagnosis involves clinical examination, smear examination, skin biopsy, culture or other tests. Differential diagnoses include syphilis, deep mycosis, cutaneous tuberculosis and others. Treatment involves physical therapy, cryotherapy, heat therapy and drug therapy with medications like sodium stibogluconate, meglumine antimonate and others.

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    CUTANEOUS LEISHMANIAOIS

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    The document discusses cutaneous leishmaniasis, caused by the protozoa Leishmania. The disease is transmitted through the bite of infected sandflies. It presents with nodules, ulcers or dry plaques on exposed parts of the body. Diagnosis involves clinical examination, smear examination, skin biopsy, culture or other tests. Differential diagnoses include syphilis, deep mycosis, cutaneous tuberculosis and others. Treatment involves physical therapy, cryotherapy, heat therapy and drug therapy with medications like sodium stibogluconate, meglumine antimonate and others.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    120 views30 pages

    Cutaneous Leishmaniasis: Caused by A Protozoa Called Leishmania Pathogenesis

    Uploaded by

    Hudh Hud
    The document discusses cutaneous leishmaniasis, caused by the protozoa Leishmania. The disease is transmitted through the bite of infected sandflies. It presents with nodules, ulcers or dry plaques on exposed parts of the body. Diagnosis involves clinical examination, smear examination, skin biopsy, culture or other tests. Differential diagnoses include syphilis, deep mycosis, cutaneous tuberculosis and others. Treatment involves physical therapy, cryotherapy, heat therapy and drug therapy with medications like sodium stibogluconate, meglumine antimonate and others.

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    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 30

    CUTANEOUS LEISHMANIASIS

    Caused by a leishmania Pathogenesis: protozoa called

    The vector host is a sandfly PHLEBOTOMUS. The disease is transmitted to the human beings by the bite of the infected sandfly.

    Primary reservoir can be humans or certain animals

    Life cycle

    CLINICAL FEATURES

    The disease can present to the doctor in our part of the world in a variety of ways INCUBUTION PERIOD 3 WEEKS TO 3 MONTHS STARTS AS INSECT BITE LIKE RASH 1. A nodule or nodules on Exposed parts of the body. 2. An ulcer or ulcers on the exposed parts of the body. 3. Dry psoriasiform plaque or plaques.

    Always examine the ulcer to check for induration

    4.Subcutaneus

    Nodules and ulcers in linear chains. relapse of the disease in a previously healed scar known as leishmaniasis recidivans Dessiminated leishmaniasis Postkalazar dermal leishmaniasis

    DESSIMINATED LEISHMANIASIS
    Clinically the disease presents as multiple papules and plaques on various parts of the body IT is very resistant to treatment

    DIAGNOSIS

    Clinical

    Smear Examination: Skin Biopsy. Culture

    DIFERENTIAL DIAGNOSIS Syphilis ,deep mycosis, cutaneous tuberculosis, Leprosy, Psoriasis ,skin tumors, dermatitis artifacta, pyoderma gangrenosum.

    TREATMENT
    PHYSICAL THERAPY

    DRUG THERAPY

    CRYOTHERAPY. Local heat therapy.

    SODIUM STIBOGLUCONATE MEGLUMINE ANTIMONATE. Ketoconazole Itraconazole Dapsone Rifampicin Allopurinal. Amphoterin B.

    LYMPHATIC SPREAD IN LEISHMANIASIS

    Such pathology can also be seen in SPOROTRICOSIS,MYCOBACTERIAL INFECTIONS

    This can be misdiagnosed if palpation to feel dermal pathology is not done


    PSORIASIFORM SKIN LESION

    PSORIASIFORM SKIN PATHOLOGY ON COVERED AREA


    Always take skin biopsy from such atypical skin lesions

    Intralesional glucantime does not work as the disease has spread through lymphatics

    Leishmaniasis simulating cellulitis

    Leishmaniasis simulating sacoidosis

    Leishmaniasis simulating basal cell carcinoma

    Awarenes about this disease is lacking

    ANNULAR SKIN LESION IN LEISHMANIASIS

    SIMILAR PATHOLOGY CAN BE SEEN IN GRANULOMA ANNULARAE,LEPROSY,FUNGAL INFECTIONS,LICHEN PLANUS,TUBERCULOSIS.

    Staph aureus and streptococal skin infections may have similar picture
    Always take history and do clinical examination

    LEISHMANIASIS SIMULATING DLE

    Steroid modified leishmaniasis

    HIV +,has developed nodules on the skin and oral mucosa,

    5 years history,chronic granulomatous inflamation,pas stain +

    Many diseases can have such like presentation


    LICHEN PLANUS PSORIASIS EPIDERMAL NEVUS LICHEN STRIATICUS

    Chronic swelling of the legs


    Gets recurrent fever with increase in swelling,pain and erythema. Good response to penicillins

    PRURITUS,FAMILY HISTORY +
    PRURITIC NODULES ON GENITALIA ARE DIAGNOSTIC

    Family history +parents first cousins

    Similar rash in perioral region,oral thrush,decrease hair growth

    Short history,fresh ulcers,unfreindly family envirnoment

    Small skin lesion used clobavate


    Steroids are not the answer for every skin rash

    ACNAE VULGARIS
    Teen age Polymorphic skin rash Papules,pustules,nodules, comedones/ Face,chest,back can be involved There is follicular plugging,increased sebum production and increase in the no of propianibacterium acnae

    Treatment includes Tetracyclines macrolides Clindamycin Synthetic vitamin a derivatives Benzyle peroxide

    ACNE ROSACIA

    Midle age,usually females,fair color There are papules and pustules with,telangiactasia, erythema, Central part of face is involved Complain of burning and eye irritation Tetracyclines and metronidazole are given

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