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    172 Triveni Uikey MGMMC Indore

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    172 Triveni Uikey MGMMC Indore

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    Triveni Uikey
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    6 views11 pages

    172 Triveni Uikey MGMMC Indore

    Uploaded by

    Triveni Uikey

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 11

    MGM medical college Indore

    topi :- Salvage pathway for purine and


    pyramidine
    presented by :Triveni Uikey (2019batch)
    motivation :Dr Manohar Bhandhri sir

    Seen discussed and finish with the help of :- Priyanshi gokhe


    Renee Coriolis d shera, Shivani Ghirwal.
    Introduction to purine
    • Purine is a heterocyclic aromatic organic compound that consists of a
    pyrimidine ring fused to an imidazole ring.
    • It is water-soluble.
    • Purines occur in all organisms as the bases of DNA and RNA
    • Examples of purines include caffeine, xanthine, hypoxanthine, uric acid,
    theobromine, and the nitrogenous bases adenine and guanine
    Salvage pathway for purine Synthesis
    • Introduction :-
    • The pathway involved in the conversion of free purine to nucleotide
    is called salvage pathway
    • Free purine are salvaged and used over again to remake purine
    nucleotide in which purine ring system is assembled step by step on
    ribose -5-phosphate .
    • Salvage pathway is much simpler and requires far less energy than
    does de novo synthesise
    Salvage pathway for purine synthesis
    • Salvage reaction :-
    • In salvage rxn ribose phosphate moiety of PRPP is transferred to the
    purine form. There are two salvage enzymes with different specificities.
    • 1)Adenine phosphoribosyl transferase :- catalyse the formation of adenine
    nucleotide (AMP) from adenine
    • 2)Hypoxanthine Guanine phosphoribosyl transferase (HGPRTase) :-
    catalyse the formation of ionosine from hypoxanthine and guanine.
    Introduction to pyramidine
    • Pyrimidine is an aromatic heterocyclic organic compound similar to
    pyridine
    • One of the three diazines (six-membered heterocyclics with two nitrogen
    atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the
    ring.
    • Pyrimidines include cytosine, thymine,
    and uracil whereas purines include adenine and guanine.
    Salvage pathway for pyramidine synthesise
    • Similar to purine pyramidine are also recoverd from derivative
    Intermediate of nucleic acid such as DNA and RNA
    • The recovery of pyramidine is catalyse by the enzyme pyramidine
    Phosphoryboslytransferase.
    • Pyramidine phosphoribosyltranferase enzyme utilise PRPP as the source
    of ribose -5- phosphate.
    Significance of salvage pathway
    • Salvage pathway provide purines nucleotide for tissues which are
    incapable to synthesize purine nucleotide by De novo pathway , e. g
    human brain, erythrocytes, and polymorphonuclear leukocytes
    Some topic related one mark questions
    • 1)Salvage pathway of purine biosynthesis Is imp for which organ?
    • 2)First purine nucleotide which is synthesised In purine biosynthesis is?
    • 3)Where does salvage pathway occur?
    • 4)What is the end product of pyramidine metabolism ?

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