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19 Microarray 26 02 2024

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gunjanbhartia2003
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9 views9 pages

19 Microarray 26 02 2024

Uploaded by

gunjanbhartia2003
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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What is GWO?

• The GWO algorithm mimics the leadership hierarchy and hunting


mechanism of grey wolves in nature.
Application
• Each microarray experiment can analyze many thousands of genes in
parallel. The outcomes of the DNA microarray is a table/matrix, called
gene expression data.
• Pattern recognition algorithms are widely applied to gene expression
data to differentiate between health and cancerous patient samples.
• However, gene expression data is characterized as a high dimensional
data that typically encompassed of redundant, noisy, and irrelevant
genes.
• Datasets with such characteristics pose a challenge to machine
learning algorithms
Application
• This is because they impede the training and testing process and entail high
resource computations that deteriorate the classification performance.
• In order to avoid these pitfalls, gene selection is needed. Gray Wolf Optimizer
(GWO) can be used to seek sets of genes.
• Microarray data help in analysing the gene expressions, and the process of
clustering helps in categorizing the data into organized groups.
• Grouping similar gene expressions paves the way for effective analysis, and
the relationship between the expressions can be figured out.
• Recognizing the benefits of clustering, clustering algorithm by combining
generalized hierarchical fuzzy C means (GHFCM) and grey wolf optimization
(GWO) algorithms has been developed.
Application
• The GWO algorithm can be utilized for selecting the initial clustering
point
• The boxplots of high-quality data show similar
width and positions, and represent the distribution
of signal intensities in the data.
• The distribution is usually done on the log scale to
make the plot readable. A major deviation in the
boxplot might represent an experimental flaw or
noise in that particular array.
A simple summary

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